ReviewArteriosclerosis, thrombosis, and vascular biology2014
Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.
Abstract readConsensus Development Conference, NIHReview
In one paragraph
Review in Arteriosclerosis, thrombosis, and vascular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
188 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association of peritoneal dialysis and hemodialysis on mitral and aortic valve calcification associated mortality: a meta-analysis.Scientific reports · 2024Pooled it
- Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial.Circulation · 2021Trial
- Cardiovascular Disease and Androgens: Clinical Trends, Potential Mechanisms, and Considerations for Engineering Solutions.Cardiovascular engineering and technology · 2026Review
- Article
- Biatrial Inflammatory and Fibrotic Remodeling in Severe Aortic Stenosis Compared with CABG Controls.Metabolites · 2026Article
- Vein graft failure: Pathophysiology, detection, prevention and emerging therapeutic strategies.Pharmacological reviews · 2026Review
- Capturing Multiscale Dynamics of Aortic Valve Calcification with a Coupled Fluid-Structure and Systems Biology Model.ACS omega · 2026Article
- Article
- Review
- Caldesmon-1-mediated actin dynamics is essential for osteogenic differentiation of aortic valve interstitial cells.Scientific reports · 2026Article
- Opportunistic automated aortic valve calcification assessment in low-cost, screening CT calcium score exams.Scientific reports · 2026Article
- Adenosine and ATP differentially control osteogenic gene expression patterns in a cardiac valve cell line.Cardiology journal · 2026Article
- Metformin mitigates aortic valve degeneration in an ex vivo three-dimensional tissue model.Scientific reports · 2025Article
- Calcified mass attached to mitral valve chordae tendineae in a dog with hyperadrenocorticism: A case report.BMC veterinary research · 2025Article
- Global, regional, and national burdens of non-rheumatic calcific aortic valve disease in middle-aged and elderly populations from 1990 to 2021 and predictions up to 2050: trends, predictions, and health inequity.European journal of medical research · 2025Article
- Observational
- Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk.Basic research in cardiology · 2025Article
- Hemodynamic Alteration in Aortic Valve Stenosis: CFD Insights from Leaflet-Resolved Models.Bioengineering (Basel, Switzerland) · 2025Article
- PTEN Regulates Myofibroblast Activation in Valvular Interstitial Cells Based on Subcellular Localization.Advanced biology · 2025Article
- Sodium-Glucose Cotransporter 2 Inhibitors in Aortic Stenosis: Toward a Comprehensive Cardiometabolic Approach.International journal of molecular sciences · 2025Review
128 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Katherine E YutzeyFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Linda L DemerFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Simon C BodyFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Gordon S HugginsFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Dwight A TowlerFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Cecilia M GiachelliFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Marion A Hofmann-BowmanFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Douglas P MortlockFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Melissa B RogersFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Mehran M SadeghiFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
Elena AikawaFrom the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). eaikawa@partners.org.
Funding
Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4MCalcification and Vascular Cell DifferentiationR01HL081785 · NHLBI · UNIVERSITY OF WASHINGTON · PI GIACHELLI, CECILIA M · 2005 to 2017
$3.7MEndocrine Regulation of Calcific Aortic Valve Sclerosis: PTH/PTHRP Receptor SignaR01HL114806 · NHLBI · WASHINGTON UNIVERSITY · PI TOWLER, DWIGHT A. · 2012 to 2016
$2.1MGenetic Etiology of Bicuspid Aortic Valve DiseaseR01HL114823 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BODY, SIMON C · 2012 to 2016
$2.1MAortic valve microcalcificationR01HL114805 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, ELENA · 2012 to 2016
$2.1MImaging protease activation in calcific aortic valve diseaseR01HL114703 · NHLBI · YALE UNIVERSITY · PI SADEGHI, MEHRAN M · 2012 to 2016
$2.0MRole of Osteoclastogenesis in Calcific Aortic Valve DiseaseR01HL114611 · NHLBI · UNIVERSITY OF WASHINGTON · PI GIACHELLI, CECILIA M · 2012 to 2016
$1.9MBasic Mechanisms of Human Calcific Aortic Valve DiseaseR01HL114794 · NHLBI · TUFTS MEDICAL CENTER · PI BLACK III, LAUREN D., HINDS, PHILIP W. · 2012 to 2015
$1.6MPro-inflammatory S100 protein as disease modifier in calcific aortic valve diseasR01HL114821 · NHLBI · UNIVERSITY OF CHICAGO · PI HOFMANN BOWMAN, MARION A · 2012 to 2015
$1.5MBMP2 Gene Regulation in Calcific Aortic Valve DiseaseR01HL114751 · NHLBI · VANDERBILT UNIVERSITY · PI MORTLOCK, DOUGLAS P, ROGERS, MELISSA B · 2012 to 2015
$1.5MRole of Inhibitory SMADs in Calcific Aortic Valve DiseaseR01HL114709 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2012 to 2015
$1.5MCell Signaling Mechanisms of Calcific Aortic Valve DiseaseR01HL114682 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI YUTZEY, KATHERINE E · 2012 to 2015
$1.5MNCATS NIH HHS UL1 TR000170NHLBI NIH HHS R01 HL081785NHLBI NIH HHS R01 HL114611NHLBI NIH HHS R01 HL114682NHLBI NIH HHS R01 HL114703NHLBI NIH HHS R01 HL114709NHLBI NIH HHS R01 HL114751NHLBI NIH HHS R01 HL114794NHLBI NIH HHS R01 HL114805NHLBI NIH HHS R01 HL114806NHLBI NIH HHS R01 HL114821NHLBI NIH HHS R01 HL114823
Abstract
Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis. This group identified CAVD as an actively regulated disease process in need of further study. As a result, the Alliance of Investigators on CAVD was formed to coordinate and promote CAVD research, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods. The group is composed of cardiologists, geneticists, imaging specialists, and basic science researchers. This report reviews the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population.
Indexed as
Aortic ValveAortic Valve StenosisBicuspid Aortic Valve DiseaseBiomedical ResearchCalcinosisCardiac Surgical ProceduresHeart Defects, CongenitalHeart Valve DiseasesHeart Valve Prosthesis ImplantationHemodynamicsHumansSignal Transductionaortic valve stenosiscalcificationinflammation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.