Evidence map›Paper›PMID 25189431›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2014

Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference.

Sheila Riazi, Natalia Kraeva, Sheila M Muldoon, James Dowling, Clara Ho, Maria-Alexandra Petre, Jerome Parness, Robert T Dirksen, Henry Rosenberg

Abstract readConference Proceedings
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Ryanodine Receptor 1-Related Myopathies: Diagnostic and Therapeutic Approaches.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Clinical treatment of malignant hyperthermia in three cases.Experimental and therapeutic medicine · 2016
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Sheila RiaziMalignant Hyperthermia Investigation Unit, Toronto General Hospital, UHN, 200 Elizabeth Street, Eaton 3-323, Toronto, ON, M5G 2C4, Canada, Sheila.Riazi@uhn.ca.
Natalia Kraeva
Sheila M Muldoon
James Dowling
Clara Ho
Maria-Alexandra Petre
Jerome Parness
Robert T Dirksen
Henry Rosenberg
Toronto General Hospital · CAUniversity of Toronto · CAHospital for Sick Children · CANia Association · USUniformed Services University of the Health Sciences · USUniversity of Pittsburgh · USUniversity of Rochester Medical Center · US

Funding

Basis of Muscle Dysfunction in Malignant Hyperthermia & Central Core DiseaseR01AR053349 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DIRKSEN, ROBERT T, HAMILTON, SUSAN L · 2006 to 2020
$8.0M
NIAMS NIH HHS AR053349NIAMS NIH HHS R01 AR053349
6 · The paper itself

Abstract

The Malignant Hyperthermia Association of the United States and the Department of Anesthesia at the University of Toronto sponsored a Scientific Conference on November 1-2, 2013 in Toronto, ON, Canada. The multidisciplinary group of experts, including clinicians, geneticists, and physiologists involved in research related to malignant hyperthermia (MH), shared new insights into the pathophysiology of diseases linked to the type-1 ryanodine receptor gene (RYR1) as well as the relationship between MH and "awake MH" conditions, such as exertional rhabdomyolysis and exertional heat illness. In addition, the molecular genetics of MH and clinical issues related to the diagnosis and management of disorders linked to RYR1 were presented. The conference also honoured Dr. David H. MacLennan for his contributions to our understanding of the genetics, pathogenesis, and treatment of MH and other RYR1-related myopathies. This report represents a summary of the proceedings of this conference.

Indexed as

Genetic VariationHumansMalignant HyperthermiaRyanodine Receptor Calcium Release ChannelRyanodine Receptor Calcium Release Channel

Identifiers

PMID25189431
PMCPMC4276369
OpenAlexW1712027044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.