ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015
Influence of chronic stroke impairments on bone strength index of the tibial distal epiphysis and diaphysis.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- The impact of stroke on bone properties and muscle-bone relationship: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Pooled it
- Effects of different vibration frequencies on muscle strength, bone turnover and walking endurance in chronic stroke.Scientific reports · 2021Trial
- Vascular Health and Cutaneous Sensation are Predictive of Upper Limb Bone Loss in People with Stroke: A 2-Year Longitudinal Study.Calcified tissue international · 2026Article
- Gait speed and spasticity are independently associated with estimated failure load in the distal tibia after stroke: an HR-pQCT study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Relationship between bone strength index of the hemiparetic tibial diaphysis and muscle strength in people with chronic stroke: influence of muscle contraction type and speed.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- SIDE TO SIDE DIFFERENCES BETWEEN DOMINANT AND NON-DOMINANT ARM'S BONE DENSITY AND ISOMETRIC HANDGRIP STRENGTH IN MALES AND FEMALES AGED 40-65 YEARS OLD.Materia socio-medica · 2016Article
- Chronic effects of stroke on hip bone density and tibial morphology: a longitudinal study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryThe influence of various stroke impairments on bone health is poorly understood. This study showed that muscle function and small artery compliance were more strongly associated with the bone strength index at the tibial diaphyseal and epiphyseal regions, respectively. These impairments should be targeted in promoting bone health post-stroke.
introductionThis study examined the bone structural properties of the tibial distal epiphysis and diaphysis after chronic stroke and identified the clinical correlates of the bone strength index measured at these sites.
methodsThe tibial distal epiphysis (4% site) and diaphysis (66% site) were scanned on both sides in 66 chronic stroke patients and 23 control participants using peripheral quantitative computed tomography. Dynamic knee muscle strength, balance function, spasticity, arterial compliance, and endurance were also measured in the stroke group.
resultsAt the 4% site, multivariate analysis showed a significant side×group interaction effect (Wilk's lambda=3.977, p<0.001), with significant side-to-side differences in total volumetric bone mineral density (vBMD), trabecular vBMD, and bone strength index in the stroke group, but not in the control group. A significant side×group interaction was also found at the 66% site (Wilk's lambda=4.464, p<0.001), with significant side-to-side differences in cortical vBMD, cortical area, cortical thickness, and bone strength index in the stroke group only. Balance and endurance were independently associated with bone strength index at both tibial sites in the paretic leg (p<0.05) after adjusting for relevant factors in multivariate regression analysis. Small artery compliance and muscle strength were significantly associated with the bone strength index at the 4% site and 66% site, respectively.
conclusionsThe influence of various stroke impairments on bone was region-specific. While muscle function was more strongly associated with the bone strength index in the diaphyseal region, the effect of vascular health was more apparent in the tibial epiphysis in the paretic leg.
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