ArticleScientific reports2014
Tuning calcite morphology and growth acceleration by a rational design of highly stable protein-mimetics.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 72 citations in OpenAlex.
- Mechanistic Insights into Molecular Modifiers That Promote Urate Crystallization through Solute Assembly Regulation.JACS Au · 2026Article
- Silica-Biomacromolecule Interactions: Toward a Mechanistic Understanding of Silicification.Biomacromolecules · 2025Review
- A molecular view of peptoid-induced acceleration of calcite growth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Rational Design and Multicomponent Synthesis of Lipid-Peptoid Nanocomposites towards a Customized Drug Delivery System Assembly.Molecules (Basel, Switzerland) · 2023Article
- Peptoid-Directed Formation of Five-Fold Twinned Au Nanostars through Particle Attachment and Facet Stabilization.Angewandte Chemie (International ed. in English) · 2022Article
- Solution Self-Assembly of Coil-Crystalline Diblock Copolypeptoids Bearing Alkyl Side Chains.Polymers · 2021Review
- Sequence-Defined Peptoids with -OH and -COOH Groups As Binders to Reduce Cracks of Si Nanoparticles of Lithium-Ion Batteries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Thermodynamic and Kinetic Parameters for Calcite Nucleation on Peptoid and Model Scaffolds: A Step toward Nacre Mimicry.Crystal growth & design · 2020Article
- Amino Acid and Oligopeptide Effects on Calcium Carbonate Solutions.Crystal growth & design · 2020Article
- Hydroxyl-rich macromolecules enable the bio-inspired synthesis of single crystal nanocomposites.Nature communications · 2019Article
- Hydroxycitrate: a potential new therapy for calcium urolithiasis.Urolithiasis · 2019Review
- Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering.Nature communications · 2018Article
- Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids.Nature communications · 2018Article
- Using biomimetic polymers in place of noncollagenous proteins to achieve functional remineralization of dentin tissues.ACS biomaterials science & engineering · 2017Article
- The role of macromolecules in the formation of kidney stones.Urolithiasis · 2017Review
- Tuning hardness in calcite by incorporation of amino acids.Nature materials · 2016Article
- Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids.Nature communications · 2016Article
- An enhanced chemiluminescence bioplatform by confining glucose oxidase in hollow calcium carbonate particles.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In nature, proteins play a significant role in biomineral formation. One of the ultimate goals of bioinspired materials science is to develop highly stable synthetic molecules that mimic the function of these natural proteins by controlling crystal formation. Here, we demonstrate that both the morphology and the degree of acceleration or inhibition observed during growth of calcite in the presence of peptoids can be rationally tuned by balancing the electrostatic and hydrophobic interactions, with hydrophobic interactions playing the dominant role. While either strong electrostatic or hydrophobic interactions inhibit growth and reduces expression of the {104} faces, correlations between peptoid-crystal binding energies and observed changes in calcite growth indicate moderate electrostatic interactions allow peptoids to weakly adsorb while moderate hydrophobic interactions cause disruption of surface-adsorbed water layers, leading to growth acceleration with retained expression of the {104} faces. This study provides fundamental principles for designing peptoids as crystallization promoters, and offers a straightforward screening method based on macroscopic crystal morphology. Because peptoids are sequence-specific, highly stable, and easily synthesized, peptoid-enhanced crystallization offers a broad range of potential applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.