ArticleScientific reports2014
Optical assay of erythrocyte function in banked blood.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Tired and stressed: direct holographic quasi-static stretching of aging echinocytes and discocytes in plasma using optical tweezers [Invited].Biomedical optics express · 2024Article
- Spatial light interference microscopy: principle and applications to biomedicine.Advances in optics and photonics · 2021Article
- Nanoscale Changes on RBC Membrane Induced by Storage and Ionizing Radiation: A Mini-Review.Frontiers in physiology · 2021Review
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- Quantitative phase imaging of erythrocytes under microfluidic constriction in a high refractive index medium reveals water content changes.Microsystems & nanoengineering · 2019Article
- Invited Article: Digital refocusing in quantitative phase imaging for flowing red blood cells.APL photonics · 2018Article
- Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging.Biomedical optics express · 2018Article
- Quantitative phase microscopy of red blood cells during planar trapping and propulsion.Lab on a chip · 2018Article
- Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM).Scientific reports · 2018Article
- Geometric localization of thermal fluctuations in red blood cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Blood storage alters mechanical stress responses of erythrocytes.Clinical hemorheology and microcirculation · 2017Article
- Measuring cell surface area and deformability of individual human red blood cells over blood storage using quantitative phase imaging.Scientific reports · 2016Article
- Lipidomic and metabolomic analysis of human erythrocytes during storage for transfusion applications.Blood transfusion = Trasfusione del sangueArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Stored red blood cells undergo numerous biochemical, structural, and functional changes, commonly referred to as storage lesion. How much these changes impede the ability of erythrocytes to perform their function and, as result, impact clinical outcomes in transfusion patients is unknown. In this study we investigate the effect of the storage on the erythrocyte membrane deformability and morphology. Using optical interferometry we imaged red blood cell (RBC) topography with nanometer sensitivity. Our time-lapse imaging quantifies membrane fluctuations at the nanometer scale, which in turn report on cell stiffness. This property directly impacts the cell's ability to transport oxygen in microvasculature. Interestingly, we found that cells which apparently maintain their normal shape (discocyte) throughout the storage period, stiffen progressively with storage time. By contrast, static parameters, such as mean cell hemoglobin content and morphology do not change during the same period. We propose that our method can be used as an effective assay for monitoring erythrocyte functionality during storage time.
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