ArticleBMC genomics2014
A genome-wide association analysis for porcine serum lipid traits reveals the existence of age-specific genetic determinants.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 28 citations in OpenAlex.
- Key co-expressed genes correlated with blood serum parameters of pigs fed with different fatty acid profile diets.Frontiers in genetics · 2024Article
- Host genetics and gut microbiota jointly regulate blood biochemical indicators in chickens.Applied microbiology and biotechnology · 2023Article
- Genomic prediction of growth in a commercially, recreationally, and culturally important marine resource, the Australian snapper (Chrysophrys auratus).G3 (Bethesda, Md.) · 2022Article
- High-Altitude Genetic Selection and Genome-Wide Association Analysis of Yield-Related Traits inFrontiers in plant science · 2022Article
- The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism.Genes & development · 2020Review
- Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs.Scientific reports · 2019Article
- Genome-wide association studies for 30 haematological and blood clinical-biochemical traits in Large White pigs reveal genomic regions affecting intermediate phenotypes.Scientific reports · 2019Article
- Identification and characterization of novel single nucleotide polymorphism markers for fat deposition in muscle tissue of pigs using amplified fragment length polymorphism.Asian-Australasian journal of animal sciences · 2017Article
- Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses.Annals of the New York Academy of Sciences · 2017Review
- Joint QTL mapping and gene expression analysis identify positional candidate genes influencing pork quality traits.Scientific reports · 2017Article
- Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.PloS one · 2017Article
- Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels.Scientific reports · 2016Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe genetic determinism of blood lipid concentrations, the main risk factor for atherosclerosis, is practically unknown in species other than human and mouse. Even in model organisms, little is known about how the genetic determinants of lipid traits are modulated by age-specific factors. To gain new insights into this issue, we have carried out a genome-wide association study (GWAS) for cholesterol (CHOL), triglyceride (TRIG) and low (LDL) and high (HDL) density lipoprotein concentrations measured in Duroc pigs at two time points (45 and 190 days).
resultsAnalysis of data with mixed-model methods (EMMAX, GEMMA, GenABEL) and PLINK showed a low positional concordance between trait-associated regions (TARs) for serum lipids at 45 and 190 days. Besides, the proportion of phenotypic variance explained by SNPs at these two time points was also substantially different. The four analyses consistently detected two regions on SSC3 (124 Mb, CHOL and LDL at 190 days) and SSC6 (135 Mb, CHOL and TRIG at 190 days) with highly significant effects on the porcine blood lipid profile. Moreover, we have found that SNP variation within SSC3, SSC6, SSC10, SSC13 and SSC16 TARs is associated with the expression of several genes mapping to other chromosomes and related to lipid metabolism.
conclusionsOur data demonstrate that the effects of genomic determinants influencing lipid concentrations in pigs, as well as the amount of phenotypic variance they explain, are influenced by age-related factors.
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