Evidence map›Paper›PMID 25189171›Full record

ArticleNature communications2014

Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.

Tao Ye, Jacque P K Ip, Amy K Y Fu, Nancy Y Ip

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Three decades of Cdk5.Journal of biomedical science · 2021
    Review
  10. Review
  11. Article
  12. Molecular Mechanisms of Cadherin Function During Cortical Migration.Frontiers in cell and developmental biology · 2020
    Review
  13. Double UP: A Dual Color, Internally Controlled Platform forFrontiers in molecular neuroscience · 2020
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tao Ye1] Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China [2] Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China [3] State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Jacque P K Ip1] Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China [2] Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China [3] State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Amy K Y Fu1] Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China [2] Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China [3] State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Nancy Y Ip1] Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China [2] Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China [3] State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Hong Kong University of Science and Technology · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During cerebral cortex development, pyramidal neurons migrate through the intermediate zone and integrate into the cortical plate. These neurons undergo the multipolar-bipolar transition to initiate radial migration. While perturbation of this polarity acquisition leads to cortical malformations, how this process is initiated and regulated is largely unknown. Here we report that the specific upregulation of the Rap1 guanine nucleotide exchange factor, RapGEF2, in migrating neurons corresponds to the timing of this polarity transition. In utero electroporation and live-imaging studies reveal that RapGEF2 acts on the multipolar-bipolar transition during neuronal migration via a Rap1/N-cadherin pathway. Importantly, activation of RapGEF2 is controlled via phosphorylation by a serine/threonine kinase Cdk5, whose activity is largely restricted to the radial migration zone. Thus, the specific expression and Cdk5-dependent phosphorylation of RapGEF2 during multipolar-bipolar transition within the intermediate zone are essential for proper neuronal migration and wiring of the cerebral cortex.

Indexed as

Cell MovementCerebral CortexCyclin-Dependent Kinase 5ElectroporationFluorescent Antibody TechniqueGene Expression Regulation, DevelopmentalGuanine Nucleotide Exchange FactorsHumansImmunohistochemistryNerve Tissue ProteinsNeuronsPhosphorylationRNA, Small InterferingCDK5 protein, humanCyclin-Dependent Kinase 5Guanine Nucleotide Exchange FactorsNerve Tissue ProteinsRAPGEF2 protein, humanRNA, Small Interfering

Identifiers

PMID25189171
PMCPMC4164783
OpenAlexW2009026745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.