ArticleOccupational and environmental medicine2014
Blood acetylcholinesterase and butyrylcholinesterase as biomarkers of cholinesterase depression among pesticide handlers.
Article in Occupational and environmental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- A Meta-Analysis of Whole Blood Cholinesterase Activity in Healthy Ruminants Using a Modified Electrometric Measurement Method.Acta medica academica · 2026Pooled it
- Comprehensive Biomarker Assessment of Pesticide Exposure and Telomere Attrition in Mexican Children from Agricultural Communities.Journal of xenobiotics · 2025Article
- Associations between pesticide exposure and hepatobiliary disease among agricultural workers in the Northeastern region of Thailand: a cross-sectional study.Journal of occupational medicine and toxicology (London, England) · 2025Article
- Hydro-Alcoholic Extract of Cynodon dactylon Ameliorates Malathion-Induced Neurocognitive Behavior and Neurotoxicity.Neuromolecular medicine · 2025Article
- Relationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from Peru.Journal of occupational medicine and toxicology (London, England) · 2025Article
- Validation of a novel questionnaire for assessing occupational exposure to organophosphate pesticides in Chilean agricultural workers.Frontiers in toxicology · 2025Article
- Whole blood cholinesterase activity in humans and ruminants: Comparison using a modified electrometric method.Open veterinary journal · 2025Article
- Effect of pesticide exposure on stunting incidence: a systematic review and meta-analysis.Clinical and experimental pediatrics · 2024Article
- Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities.Exposure and health · 2024Article
- Organophosphorus Poisoning: Acute Respiratory Distress Syndrome (ARDS) and Cardiac Failure as Cause of Death in Hospitalized Patients.International journal of molecular sciences · 2023Review
- Time after a peak-pesticide use period and neurobehavior among ecuadorian children and adolescents: The ESPINA study.Environmental research · 2022Article
- Pesticide toxicity assessment and geographic information system (GIS) application in small-scale rice farming operations, Thailand.Scientific reports · 2022Article
- Article
- Assessment of Cytogenetic Damage and Cholinesterases' Activity in Workers Occupationally Exposed to Pesticides in Zamora-Jacona, Michoacan, Mexico.International journal of environmental research and public health · 2021Article
- Pesticide exposure and adverse health effects associated with farmwork in Northern Thailand.Journal of occupational health · 2021Article
- Reduced neurobehavioral functioning in agricultural workers and rural inhabitants exposed to pesticides in northern Chile and its association with blood biomarkers inhibition.Environmental health : a global access science source · 2020Article
- Pharmacokinetics of Two Chlorine-Substituted Bis-Pyridinium Mono-Aldoximes with Regenerating Effect on Butyrylcholinesterase.Molecules (Basel, Switzerland) · 2020Article
- Pesticide Use and Serum Acetylcholinesterase Levels among Flower Farm Workers in Ethiopia-A Cross-Sectional Study.International journal of environmental research and public health · 2020Article
- Poisoning Cases Reported to Poison Information Centre, Ahmedabad, India: A Three Year Observational Study.Central Asian journal of global health · 2020Article
- Blood pressure after a heightened pesticide spray period among children living in agricultural communities in Ecuador.Environmental research · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAgricultural pesticide handlers are at an elevated risk for overexposure to organophosphate (OP) pesticides, but symptoms can be difficult to recognise, making biomarkers invaluable for diagnosis. Occupational monitoring programmes for cholinesterase depression generally rely on measuring activity of either of the two common blood cholinesterases which serve as proxy measurements for nervous-system acetylcholinesterase activity: red blood cell acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE). These biomarkers, however, may be affected differentially by some OPs and the relationship between them has not been well characterised. We aim to determine the association between blood AChE and BChE activity levels and assess whether they produce comparable classifications of clinical cholinesterase depression among OP pesticide handlers.
methodsUsing blood samples from 215 participants of the Washington State Cholinesterase Monitoring Program, we quantified changes in AChE and BChE activity from before and after exposure to OP pesticides and calculated Pearson correlation statistics for correlation of AChE and BChE changes in activity, as well as weighted κ statistics for agreement of classification of clinical cholinesterase depression based on AChE versus BChE measurements.
resultsAChE and BChE activity measurements are weakly negatively correlated in our study population. Reaching a clinical threshold for diagnosis of cholinesterase depression based on the AChE marker did not correlate with reaching clinical depression based on the BChE marker.
conclusionsBoth AChE and BChE should be measured in monitoring programmes because they may both give potentially important but disparate classifications of clinical cholinesterase depression.
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