ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
The impacts of severe perfusion defects, akinetic/dyskinetic segments, and viable myocardium on the accuracy of volumes and LVEF measured by gated ⁹⁹mTc-MIBI SPECT and gated ¹⁸F-FDG PET in patients with left ventricular aneurysm: cardiac magnetic resonance imaging as the reference.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
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- Objective, observer-independent evaluation of myocardial perfusion and function: role of SPECT.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Review
- Prognostic value of ventricular mechanical dyssynchrony in patients with left ventricular aneurysm: A comparative study of medical and surgical treatment.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
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- Putting gated SPECT and PET left ventricular function computations in perspective.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Evaluation of left ventricular volumes and ejection fraction byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Impact of revascularization in patients with post-infarction left ventricular aneurysm and ventricular tachyarrhythmia.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021Article
- Left ventricular mechanical dyssynchrony analzyed by Tc-99m sestamibi SPECT and F-18 FDG PET in patients with ischemic cardiomyopathy and the prognostic value.The international journal of cardiovascular imaging · 2020Article
- Cardiac death in patients with left ventricular aneurysm, remodeling and myocardial viability by gatedThe international journal of cardiovascular imaging · 2018Article
- Calculation of left ventricular volumes and ejection fraction from dynamic cardiac-gatedEJNMMI physics · 2017Article
- Evaluation of ECG-gated [(11)C]acetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo compare the accuracy of end-diastolic and end-systolic volumes (EDV, ESV) and LV ejection fraction (LVEF) measured by both GSPECT and GPET, using cardiac magnetic resonance imaging (CMR) as a reference. Furthermore, the impacts of severe perfusion defects, akinetic/dyskinetic segments, and residual viable myocardium on the accuracy of LV functional parameters were investigated.
methodsNinety-six consecutive patients with LV aneurysm and LV dysfunction (LVEF 32 ± 9%) diagnosed by CMR were studied with GSPECT and GPET. EDV, ESV, and LVEF were calculated using QGS software.
resultsCorrelations of volumes were excellent (r 0.81-0.86) and correlation of LVEF was moderate (r 0.65-0.76) between GSPECT vs CMR and between GPET vs CMR. Compared with CMR, ESV was overestimated by GSPECT (P < .01) and underestimated by GPET (P < .0001); EDV was underestimated by GPET (P < .001); LVEF was underestimated by GSPECT but overestimated by GPET (both P < .001). Multivariate regression analysis revealed that the number of segments with severe perfusion defects (P < .001) was the only independent factor which was correlated to the EDV difference between GSPECT and CMR, the number of akinetic/dyskinetic segments with absent wall thickening (WT) was the only independent factor which was significantly correlated to the differences of ESV and LVEF measurements between GSPECT vs CMR and between GPET vs CMR (P < .0001), respectively. Neither the mismatch score nor the segments with viable myocardium were correlated to the differences of LV volumes and LVEF measurements between different imaging modalities.
conclusionsIn LV aneurysm patients, LV volumes and LVEF measured by both GSPECT and GPET imaging correlated well with those determined by CMR, but should not be interchangeable in individual patients. The accuracy of LVEF measured by GSPECT and GPET was affected by the akinetic/dyskinetic segments with absent WT.
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