Evidence map›Paper›PMID 25188498›Full record

Observational studyPloS one2014

Fetal gender and several cytokines are associated with the number of fetal cells in maternal blood--an observational study.

Jacob Mørup Schlütter, Ida Kirkegaard, Olav Bjørn Petersen, Nanna Larsen, Britta Christensen, David M Hougaard, Steen Kølvraa, Niels Uldbjerg

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Ambient air pollution and inflammatory effects in a Canadian pregnancy cohort.Environmental epidemiology (Philadelphia, Pa.) · 2021
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jacob Mørup SchlütterDepartment of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Aarhus, Denmark.
Ida KirkegaardDepartment of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Aarhus, Denmark.
Olav Bjørn PetersenDepartment of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Aarhus, Denmark.
Nanna LarsenDepartment of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark.
Britta ChristensenFCMB ApS, Vejle, Denmark.
David M HougaardDepartment of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark.
Steen KølvraaDepartment of Clinical Genetics, University of Southern Denmark, Vejle Hospital, Vejle, Denmark.
Niels UldbjergDepartment of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Aarhus, Denmark.
Aarhus University Hospital · DKStatens Serum Institut · DKUniversity of Southern Denmark · DKVejle Sygehus · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify factors influencing the number of fetal cells in maternal blood.

methodsA total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification.

resultsParticipants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood.

conclusionThe number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.

Indexed as

AdultCell CountCell LineageCell SeparationCell TrackingChemokine CCL5FemaleFetal BloodFetusGestational AgeHumansInterleukin-2Interleukin-5MalePregnancySex CharacteristicsCCL5 protein, humanChemokine CCL5IL5 protein, humanInterleukin-2Interleukin-5

Identifiers

PMID25188498
PMCPMC4154776
OpenAlexW2023780756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.