ArticlePloS one2014
Characterization of a spontaneous retinal neovascular mouse model.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Murine models of neovascular AMD revisited: Mechanistic pathways, immune-metabolic crosstalk, and the impact of aging and sex.Experimental eye research · 2026Review
- MSC-Derived Exosomal lnc-AGT-3: A Novel Anti-Angiogenic Target in Age-Related Macular Degeneration Through p53 Signaling Pathway.Aging cell · 2026Article
- In Vivo Imaging of Rodent Retina in Retinal Disease.Methods in molecular biology (Clifton, N.J.) · 2025Article
- JR5558 mice are a reliable model to investigate subretinal fibrosis.Scientific reports · 2024Article
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- Relation of interdigitation zone changes and right-angle vessels in Macular Telangiectasia Type-2 (MacTel).Eye (London, England) · 2023Article
- Article
- Delineating effects of angiopoietin-2 inhibition on vascular permeability and inflammation in models of retinal neovascularization and ischemia/reperfusion.Frontiers in cellular neuroscience · 2023Article
- A Splicing Mutation inInternational journal of molecular sciences · 2022Article
- Clinical Pathological Features and Current Animal Models of Type 3 Macular Neovascularization.Frontiers in neuroscience · 2021Review
- A new rat model of treatment-naive quiescent choroidal neovascularization induced by human VEGF165 overexpression.Biology open · 2020Article
- Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics.Nature communications · 2020Article
- Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma.JCI insight · 2019Article
- Adgrf5 contributes to patterning of the endothelial deep layer in retina.Angiogenesis · 2019Article
- Efficacy of simultaneous VEGF-A/ANG-2 neutralization in suppressing spontaneous choroidal neovascularization.EMBO molecular medicine · 2019Article
- Reliability and reproducibility of a rodent model of choroidal neovascularization based on the subretinal injection of polyethylene glycol.Molecular vision · 2019Article
- Overlap between telangiectasia and photoreceptor loss increases with progression of macular telangiectasia type 2.PloS one · 2019Article
- Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele.Investigative ophthalmology & visual science · 2018Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundVision loss due to vascular disease of the retina is a leading cause of blindness in the world. Retinal angiomatous proliferation (RAP) is a subgroup of neovascular age-related macular degeneration (AMD), whereby abnormal blood vessels develop in the retina leading to debilitating vision loss and eventual blindness. The novel mouse strain, neoretinal vascularization 2 (NRV2), shows spontaneous fundus changes associated with abnormal neovascularization. The purpose of this study is to characterize the induction of pathologic angiogenesis in this mouse model.
methodsThe NRV2 mice were examined from postnatal day 12 (p12) to 3 months. The phenotypic changes within the retina were evaluated by fundus photography, fluorescein angiography, optical coherence tomography, and immunohistochemical and electron microscopic analysis. The pathological neovascularization was imaged by confocal microscopy and reconstructed using three-dimensional image analysis software.
resultsWe found that NRV2 mice develop multifocal retinal depigmentation in the posterior fundus. Depigmented lesions developed vascular leakage observed by fluorescein angiography. The spontaneous angiogenesis arose from the retinal vascular plexus at postnatal day (p)15 and extended toward retinal pigment epithelium (RPE). By three months of age, histological analysis revealed encapsulation of the neovascular lesion by the RPE in the photoreceptor cell layer and subretinal space.
conclusionsThe NRV2 mouse strain develops early neovascular lesions within the retina, which grow downward towards the RPE beginning at p15. This retinal neovascularization model mimics early stages of human retinal angiomatous proliferation (RAP) and will likely be a useful in elucidating targeted therapeutics for patients with ocular neovascular disease.
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