ArticlePLoS computational biology2014
Emergence of assortative mixing between clusters of cultured neurons.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Network Bursts in 3D Neuron Clusters Cultured on Microcontact-Printed Substrates.Micromachines · 2023Article
- Modular architecture facilitates noise-driven control of synchrony in neuronal networks.Science advances · 2023Article
- Structural Modularity Tunes Mesoscale Criticality in Biological Neuronal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Long-term calcium imaging reveals functional development in hiPSC-derived cultures comparable to human but not rat primary cultures.Stem cell reports · 2023Article
- Dynamic and Functional Alterations of Neuronal Networks In Vitro upon Physical Damage: A Proof of Concept.Micromachines · 2022Article
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- Flexibility ofFrontiers in cellular neuroscience · 2022Article
- Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Dynamics of Structured Networks of Winfree Oscillators.Frontiers in systems neuroscience · 2021Article
- Network science characteristics of brain-derived neuronal cultures deciphered from quantitative phase imaging data.Scientific reports · 2020Article
- Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures.Network neuroscience (Cambridge, Mass.) · 2020Article
- Impact of Physical Obstacles on the Structural and Effective Connectivity ofFrontiers in computational neuroscience · 2020Article
- Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth.eLife · 2019Article
- Article
- Impact of modular organization on dynamical richness in cortical networks.Science advances · 2018Article
- Dynamic graph metrics: Tutorial, toolbox, and tale.NeuroImage · 2018Article
- Assortative mixing in spatially-extended networks.Scientific reports · 2018Article
- On the nature and use of models in network neuroscience.Nature reviews. Neuroscience · 2018Review
- Mesoscale Architecture Shapes Initiation and Richness of Spontaneous Network Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Disruption of rich club organisation in cerebral small vessel disease.Human brain mapping · 2017Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to unravel the interplay between structure and functionality of neuronal systems. Here, we monitor the spontaneous self-sustained dynamics in neuronal cultures formed by interconnected aggregates of neurons (clusters). Dynamics is characterized by the fast activation of groups of clusters in sequences termed bursts. The analysis of the time delays between clusters' activations within the bursts allows the reconstruction of the directed functional connectivity of the network. We propose a method to statistically infer this connectivity and analyze the resulting properties of the associated complex networks. Surprisingly enough, in contrast to what has been reported for many biological networks, the clustered neuronal cultures present assortative mixing connectivity values, meaning that there is a preference for clusters to link to other clusters that share similar functional connectivity, as well as a rich-club core, which shapes a 'connectivity backbone' in the network. These results point out that the grouping of neurons and the assortative connectivity between clusters are intrinsic survival mechanisms of the culture.
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