ArticleDiabetes technology & therapeutics2014
Multicenter closed-loop/hybrid meal bolus insulin delivery with type 1 diabetes.
Article in Diabetes technology & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Randomized Crossover Comparison of Automated Insulin Delivery Versus Conventional Therapy Using an Unlocked Smartphone with Scheduled Pasta and Rice Meal Challenges in the Outpatient Setting.Diabetes technology & therapeutics · 2020Trial
- Performance of the Omnipod Personalized Model Predictive Control Algorithm with Meal Bolus Challenges in Adults with Type 1 Diabetes.Diabetes technology & therapeutics · 2018Trial
- Impact of erroneous meal insulin bolus with dual-hormone artificial pancreas using a simplified bolus strategy - A randomized controlled trial.Scientific reports · 2018Trial
- Improved Postprandial Glycemic Control with Faster-Acting Insulin Aspart in Patients with Type 1 Diabetes Using Continuous Subcutaneous Insulin Infusion.Diabetes technology & therapeutics · 2017Trial
- Randomized Crossover Comparison of Personalized MPC and PID Control Algorithms for the Artificial Pancreas.Diabetes care · 2016Trial
- Early Stages of Automated Insulin Delivery.Journal of diabetes science and technology · 2025Review
- Early Stages of Automated Insulin Delivery.Diabetes technology & therapeutics · 2025Review
- First validity testing of GluciQuizz, a French self-questionnaire evaluating carb-counting for patients with type 1 diabetes.PloS one · 2025Article
- Evaluating Deep Q-Learning Algorithms for Controlling Blood Glucose in In Silico Type 1 Diabetes.Diagnostics (Basel, Switzerland) · 2023Article
- Factors Beyond Carbohydrate to Consider When Determining Meantime Insulin Doses: Protein, Fat, Timing, and Technology.Diabetes spectrum : a publication of the American Diabetes Association · 2020Article
- Pharmacological Properties of Faster-Acting Insulin Aspart.Current diabetes reports · 2017Review
- Psychological Reactions Associated With Continuous Glucose Monitoring in Youth.Journal of diabetes science and technology · 2016Review
- Artificial Pancreas Device Systems for the Closed-Loop Control of Type 1 Diabetes: What Systems Are in Development?Journal of diabetes science and technology · 2016Review
- Progress in Diabetes Technology: Developments in Insulin Pumps, Continuous Glucose Monitors, and Progress towards the Artificial Pancreas.The Journal of pediatrics · 2016Article
- Continuous Glucose Monitoring: A Review of Successes, Challenges, and Opportunities.Diabetes technology & therapeutics · 2016Review
- Design and Evaluation of a Robust PID Controller for a Fully Implantable Artificial Pancreas.Industrial & engineering chemistry research · 2015Article
- GoCARB in the Context of an Artificial Pancreas.Journal of diabetes science and technology · 2015Article
Corrections and comments
- Erratum issuedCorrection.2015 · Vistenin, Roberto [corrected to Visentin, Roberto]
Authors and funding
15 authors at 11 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study evaluated meal bolus insulin delivery strategies and associated postprandial glucose control while using an artificial pancreas (AP) system. SUBJECTS AND
methodsThis study was a multicenter trial in 53 patients, 12-65 years of age, with type 1 diabetes for at least 1 year and use of continuous subcutaneous insulin infusion for at least 6 months. Four different insulin bolus strategies were assessed: standard bolus delivered with meal (n=51), standard bolus delivered 15 min prior to meal (n=40), over-bolus of 30% delivered with meal (n=40), and bolus purposely omitted (n=46). Meal carbohydrate (CHO) intake was 1 g of CHO/kg of body weight up to a maximum of 100 g for the first three strategies or up to a maximum of 50 g for strategy 4.
resultsOnly three of 177 meals (two with over-bolus and one with standard bolus 15 min prior to meal) had postprandial blood glucose values of <60 mg/dL. Postprandial hyperglycemia (blood glucose level >180 mg/dL) was prolonged for all four bolus strategies but was shorter for the over-bolus (41% of the 4-h period) than the two standard bolus strategies (73% for each). Mean postprandial blood glucose level was 15.9 mg/dL higher for the standard bolus with meal compared with the prebolus (baseline-adjusted, P=0.07 for treatment effect over the 4-h period).
conclusionsThe AP handled the four bolus situations safely, but at the expense of having elevated postprandial glucose levels in most subjects. This was most likely secondary to suboptimal performance of the algorithm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.