ArticlePLoS genetics2014
Role for circadian clock genes in seasonal timing: testing the Bünning hypothesis.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Splicing of a core circadian clock gene regulates seasonal adaptations by a winter gating mechanism.Science advances · 2026Article
- Splicing of a core clock gene regulates seasonal adaptations by a winter gating mechanism.bioRxiv : the preprint server for biology · 2025Article
- A short photoperiod alters brain metabolism and cold resistance in Drosophila melanogaster.Scientific reports · 2025Article
- Integration of photoperiodic and temperature cues by the circadian clock to regulate insect seasonal adaptations.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Unveiling Subtle Geographical Clines: Phenotypic Effects and Dynamics of Circadian Clock Gene Polymorphisms.Biology · 2023Article
- Divergence in cell cycle progression is associated with shifted phenology in a multivoltine moth: the European corn borer, Ostrinia nubilalis.The Journal of experimental biology · 2023Article
- Seasonal cues act through the circadian clock and pigment-dispersing factor to control EYES ABSENT and downstream physiological changes.Current biology : CB · 2023Article
- Clock gene-dependent glutamate dynamics in the bean bug brain regulate photoperiodic reproduction.PLoS biology · 2022Article
- Natural alleles of the clock geneFrontiers in physiology · 2022Article
- Oviposition-promoting pars intercerebralis neurons showProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Deep longitudinal multiomics profiling reveals two biological seasonal patterns in California.Nature communications · 2020Article
- Monarch Butterfly Migration Moving into the Genetic Era.Trends in genetics : TIG · 2020Review
- Phenology-dependent cold exposure and thermal performance of Ostrinia nubilalis ecotypes.BMC evolutionary biology · 2020Article
- Photoperiodic and clock regulation of the vitamin A pathway in the brain mediates seasonal responsiveness in the monarch butterfly.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evolutionary and functional genetics of insect diapause: a call for greater integration.Current opinion in insect science · 2019Review
- Photoperiodic Regulation of Shoot Apical Growth in Poplar.Frontiers in plant science · 2018Article
- TheEcology and evolution · 2017Article
- Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease.Nature communications · 2017Article
- Adaptive patterns of phenotypic plasticity in laboratory and field environments in Drosophila melanogaster.Evolution; international journal of organic evolution · 2017Article
- Physiological and molecular mechanisms underlying photoperiodism in the spider mite: comparisons with insects.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A major question in chronobiology focuses around the "Bünning hypothesis" which implicates the circadian clock in photoperiodic (day-length) measurement and is supported in some systems (e.g. plants) but disputed in others. Here, we used the seasonally-regulated thermotolerance of Drosophila melanogaster to test the role of various clock genes in day-length measurement. In Drosophila, freezing temperatures induce reversible chill coma, a narcosis-like state. We have corroborated previous observations that wild-type flies developing under short photoperiods (winter-like) exhibit significantly shorter chill-coma recovery times (CCRt) than flies that were raised under long (summer-like) photoperiods. Here, we show that arrhythmic mutant strains, per01, tim01 and ClkJrk, as well as variants that speed up or slow down the circadian period, disrupt the photoperiodic component of CCRt. Our results support an underlying circadian function mediating seasonal daylength measurement and indicate that clock genes are tightly involved in photo- and thermo-periodic measurements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.