Evidence map›Paper›PMID 25188234›Full record

Observational studyChest2015

Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study.

Kimberly A Fisher, Mihaela S Stefan, Chad Darling, Darleen Lessard, Robert J Goldberg

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Chest, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. PrehospitaL Ultrasound in Undifferentiated DyspnEa (PreLUDE): a prospective, clinical, observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023
    Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Insights into Chronic Obstructive Pulmonary Disease as Critical Risk Factor for Cardiovascular Disease.International journal of chronic obstructive pulmonary disease · 2020
    Review
  17. Article
  18. Article
  19. Article
  20. The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kimberly A FisherDepartment of Medicine, University of Massachusetts Medical School, Worcester.
Mihaela S StefanDepartment of Medicine, Baystate Medical Center, Springfield, MA.
Chad DarlingDepartment of Emergency Medicine, University of Massachusetts Medical School, Worcester.
Darleen LessardDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.
Robert J GoldbergDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester. Electronic address: Robert.Goldberg@umassmed.edu.

Funding

Monitoring Community Trends in Heart FailureR37HL069874 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GOLDBERG, ROBERT JOEL · 2002 to 2011
$6.7M
Tufts Clinical and Translation Science Institute (UL1)UL1TR000073 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2012 to 2013
$5.5M
Comparing Noninvasive and Invasive Ventilation in Acute Respiratory FailureK01HL114631 · NHLBI · BAYSTATE MEDICAL CENTER, INC. · PI STEFAN, MIHAELA S · 2013 to 2016
$565k
NCATS NIH HHS UL1 TR000073NHLBI NIH HHS K01 HL114631NHLBI NIH HHS R37 HL069874NHLBI NIH HHS R37 HL69874
6 · The paper itself

Abstract

backgroundCOPD is a common comorbidity in patients with heart failure, yet little is known about the impact of this condition in patients with acute decompensated heart failure (ADHF), especially from a more generalizable, community-based perspective. The primary objective of this study was to describe the in-hospital and postdischarge mortality and treatment of patients hospitalized with ADHF according to COPD status.

methodsThe study population consisted of patients hospitalized with ADHF at all 11 medical centers in central Massachusetts during four study years: 1995, 2000, 2002, and 2004. Patients were followed through 2010 for determination of their vital status.

resultsOf the 9,748 patients hospitalized with ADHF during the years under study, 35.9% had a history of COPD. The average age of this population was 76.1 years, 43.9% were men, and 93.3% were white. At the time of hospital discharge, patients with COPD were less likely to have received evidence-based heart failure medications, including β-blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, than patients without COPD. Multivariable, adjusted in-hospital death rates were similar for patients with and without COPD. However, among patients who survived to hospital discharge, patients with COPD had a significantly higher risk of dying at 1 year (adjusted relative risk [RR], 1.10; 95% CI, 1.06-1.14) and 5 years (adjusted RR, 1.40; 95% CI, 1.28-1.52) after hospital discharge than patients who were not previously diagnosed with COPD.

conclusionsCOPD is a common comorbidity in patients hospitalized with ADHF and is associated with a worse long-term prognosis. Further research is required to understand the complex interactions of these diseases and ensure that patients with ADHF and COPD receive optimal treatment modalities.

Indexed as

Hospital MortalityInpatientsAcute DiseaseAdrenergic beta-AntagonistsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsComorbidityFemaleHeart FailureHumansMaleMassachusettsOutpatientsPulmonary Disease, Chronic ObstructiveRetrospective StudiesAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme Inhibitors

Identifiers

PMID25188234
PMCPMC4347532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.