ArticleExperimental and therapeutic medicine2014
Clinical significance of interleukin-6, tumor necrosis factor-α and high-sensitivity C-reactive protein in neonates with hypoxic-ischemic encephalopathy.
Article in Experimental and therapeutic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Neonatal Encephalopathy biomarkers: outcome prediction from blood samples: systematic review and meta-analysis.Pediatric research · 2026Pooled it
- Umbilical cord milking for neonates who are depressed at birth: a randomized trial of feasibility.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Analysis of Energy Metabolism and Lipid Spatial Distribution in Hypoxic-Ischemic Encephalopathy Revealed by MALDI-MSI.Biomedicines · 2025Article
- White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer's disease continuum.Neurobiology of aging · 2023Article
- The association between early-onset sepsis and neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Therapeutic Hypothermia Modulates the Relationships Between Indicators of Severity of Neonatal Hypoxic Ischemic Encephalopathy and Serum Biomarkers.Frontiers in neurology · 2021Article
- Evaluation of the role of ischemia modified albumin in neonatal hypoxic-ischemic encephalopathy.Clinical and experimental pediatrics · 2020Article
- Management of Multi Organ Dysfunction in Neonatal Encephalopathy.Frontiers in pediatrics · 2020Review
- Interleukins in diagnosis of perinatal asphyxia: A systematic review.International journal of reproductive biomedicine · 2019Article
- A correction formula for neuron-specific enolase measurement in hemolyzed neonatal serum samples.Biomedical reports · 2018Article
- Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2018Article
- Biomarkers of hepatic injury and function in neonatal hypoxic ischemic encephalopathy and with therapeutic hypothermia.European journal of pediatrics · 2017Article
- A Controversial Medicolegal Issue: Timing the Onset of Perinatal Hypoxic-Ischemic Brain Injury.Mediators of inflammation · 2017Review
- Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy.Open medicine (Warsaw, Poland) · 2016Article
- Blood Biomarkers for Evaluation of Perinatal Encephalopathy.Frontiers in pharmacology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to investigate the potential roles of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (Hs-CRP) in the progression and prognosis of neonatal hypoxic-ischemic encephalopathy (HIE). The observation group comprised 74 neonates with HIE and the control group comprised 74 healthy neonates. The serum levels of IL-6, TNF-α and Hs-CRP were measured in the patients with HIE and the normal control infants. The correlations between the variances in the levels of these inflammatory cytokines and the different clinical gradings and prognoses of the disease were analyzed. The data revealed significant upregulation of the serum levels of IL-6, TNF-α and Hs-CRP in patients with HIE. The increase in the levels of these inflammatory mediators correlated with the severity of the disease and also had a positive correlation with the prognosis of the disease. In conclusion, high levels of IL-6, TNF-α and Hs-CRP were observed in neonatal patients with HIE. Thus, these inflammatory mediators may play a role in the progression and prognosis of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.