Evidence map›Paper›PMID 25187675›Full record

ArticleBiology of sport2014

Effect of exercise training of different intensities on anti-inflammatory reaction in streptozotocin-induced diabetic rats.

J-S Kim, Y-H Lee, J-C Kim, Y-H Ko, C-S Yoon, H-K Yi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sport, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
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  11. Impacts of exercise intervention on various diseases in rats.Journal of sport and health science · 2020
    Review
  12. Article
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  18. Effect of vitamin E succinate on inflammatory cytokines induced by high-intensity interval training.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

J-S KimDepartment of Oral Biochemistry, Institute of Oral Bioscience, BK21 program, School of Dentistry ; Department of Sports Science, College of Natural Science ; Department of Physical Education, College of Education, Chonbuk National University, Jeonju, Korea.
Y-H LeeDepartment of Oral Biochemistry, Institute of Oral Bioscience, BK21 program, School of Dentistry.
J-C KimDepartment of Sports Science, College of Natural Science.
Y-H KoDepartment of Physical Education, College of Education, Chonbuk National University, Jeonju, Korea.
C-S YoonDepartment of Physical Education, College of Education, Chonbuk National University, Jeonju, Korea.
H-K YiDepartment of Oral Biochemistry, Institute of Oral Bioscience, BK21 program, School of Dentistry.
Jeonbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study investigated the effect of high- and low-intensity exercise training on inflammatory reaction of blood and skeletal muscle in streptozotocin (STZ)-induced diabetic male Sprague-Dawley rats (243 ± 7 g, 8 weeks). The rats completed treadmill running in either high-intensity exercise (6 weeks of exercise training, acute bouts of exercise) or low-intensity exercise (6 weeks of exercise training). Non-running, sedentary rats served as controls. To induce diabetes mellitus, rats received a peritoneal injection of STZ (50 mg · kg(-1)). Rats were sacrificed immediately after an acute bout of exercise and 6 weeks of exercise training. Inflammatory factors were analyzed by ELISA and by immune blotting from the soleus and extensor digitorum longus muscles. In the serum, inflammatory cytokines (IL-1β, TNF-α, IL-6, IL-4) and reactive oxygen species (ROS) (nitric oxide and malondialdehyde) increased in diabetic rats. However, all exercise training groups displayed reduced inflammatory cytokines and reactive oxygen species. In skeletal muscles, low-intensity exercise training, but not high intensity exercise, reduced the levels of COX-2, iNOS, and MMP-2, which were otherwise markedly elevated in the presence of STZ. Moreover, the levels of GLUT-4 and MyoD were effectively increased by different exercise intensity and exercise duration. Low-intensity exercise training appeared most effective to reduce diabetes-related inflammation. However, high-intensity training also reduced inflammatory factors in tissue-specific muscles. The data implicate regular exercise in protecting against chronic inflammatory diseases, such as diabetes.

Indexed as

diabetes mellitusGLUT-4inflammationintensity exercise trainingMyoDROS

Identifiers

PMID25187675
PMCPMC3994589
OpenAlexW2167140921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.