ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- TLR7 in channel catfish (Ictalurus punctatus) is expressed in the endolysosome and is stimulated by synthetic ssRNA analogs, imiquimod, and resiquimod.Developmental and comparative immunology · 2024Article
- Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity.International journal of molecular sciences · 2023Review
- An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling.Traffic (Copenhagen, Denmark) · 2022Article
- N-glycosylation of UNC93B1 at a Specific Asparagine Residue Is Required for TLR9 Signaling.Frontiers in immunology · 2022Article
- Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides.Nucleic acids research · 2021Article
- CpG ODN as an adjuvant arouses the vigor of B cells by relieving the negative regulation of surface TLR9 to enhance the antibody response to vaccine.Applied microbiology and biotechnology · 2021Article
- Rational design of antisense oligonucleotides modulating the activity of TLR7/8 agonists.Nucleic acids research · 2020Article
- Cell Surface Expression of Endosomal Toll-Like Receptors-A Necessity or a Superfluous Duplication?Frontiers in immunology · 2020Review
- The sensing of mitochondrial DAMPs by non-immune cells.Cell stress · 2019Review
- The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.Immunity · 2018Article
- Constitutively Bound EGFR-Mediated Tyrosine Phosphorylation of TLR9 Is Required for Its Ability To Signal.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Diagnostic Tools for Inborn Errors of Human Immunity (Primary Immunodeficiencies and Immune Dysregulatory Diseases).Current allergy and asthma reports · 2018Review
- CD11c+ T-bet+ memory B cells: Immune maintenance during chronic infection and inflammation?Cellular immunology · 2017Review
- TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.The Journal of experimental medicine · 2017Article
- The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome.Frontiers in immunology · 2017Review
- Molecular mechanisms of regulation of Toll-like receptor signaling.Journal of leukocyte biology · 2016Review
- TLR9 stability and signaling are regulated by phosphorylation and cell stress.Journal of leukocyte biology · 2016Article
- Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA.EMBO reports · 2015Article
- Synthesis of an arrayed sgRNA library targeting the human genome.Scientific reports · 2015Article
- Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance.Cellular and molecular life sciences : CMLS · 2015Review
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
Abstract
Sensing of nucleic acids by TLRs is crucial in the host defense against viruses and bacteria. Unc-93 homolog B1 (UNC93B1) regulates the trafficking of nucleic acid-sensing TLRs from the endoplasmic reticulum to endolysosomes, where the TLRs encounter their respective ligands and become activated. In this article, we show that a carboxyl-terminal tyrosine-based sorting motif (YxxΦ) in UNC93B1 differentially regulates human nucleic acid-sensing TLRs in a receptor- and ligand-specific manner. Destruction of YxxΦ abolished TLR7, TLR8, and TLR9 activity toward nucleic acids in human B cells and monocytes, whereas TLR8 responses toward small molecules remained intact. YxxΦ in UNC93B1 influenced the subcellular localization of human UNC93B1 via both adapter protein complex (AP)1- and AP2-dependent trafficking pathways. However, loss of AP function was not causal for altered TLR responses, suggesting AP-independent functions of YxxΦ in UNC93B1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.