ArticleProceedings of the National Academy of Sciences of the United States of America2014
Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 77 citations in OpenAlex.
- Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.Science translational medicine · 2019Trial
- Trial
- Mechanisms of transcranial magnetic brain stimulation.Physiological reviews · 2026Review
- Cellular Mechanisms of Transcranial Magnetic Stimulation in Climbing Fibers and Purkinje Neurons in the Cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Structural neural plasticity evoked by rapid-acting antidepressant interventions.Nature reviews. Neuroscience · 2025Review
- Induction of excitatory brain state governs plastic functional changes in visual cortical topology.Brain structure & function · 2024Review
- Dissociation of Centrally and Peripherally Induced Transcranial Magnetic Stimulation Effects in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Magnetic Stimulation as a Therapeutic Approach for Brain Modulation and Repair: Underlying Molecular and Cellular Mechanisms.International journal of molecular sciences · 2023Review
- Repetitive transcranial magnetic stimulation (rTMS) triggers dose-dependent homeostatic rewiring in recurrent neuronal networks.PLoS computational biology · 2023Article
- Subject-specific whole-brain parcellations of nodes and boundaries are modulated differently under 10 Hz rTMS.Scientific reports · 2023Article
- The phase of plasticity-induced neurochemical changes of high-frequency repetitive transcranial magnetic stimulation are different from visual perceptual learning.Scientific reports · 2023Article
- Cortical excitability in human somatosensory and visual cortex: implications for plasticity and learning - a minireview.Frontiers in human neuroscience · 2023Review
- Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Review
- Mindfulness-based cognitive therapy combined with repetitive transracial magnetic stimulation (rTMS) on information processing and working memory of patients with multiple sclerosis.Caspian journal of internal medicine · 2022Article
- Brain circuits for pain and its treatment.Science translational medicine · 2021Review
- Transcranial magnetic stimulation alters multivoxel patterns in the absence of overall activity changes.Human brain mapping · 2021Article
- Transcranial magnetic stimulation over the right dorsolateral prefrontal cortex modulates visuospatial distractor suppression.The European journal of neuroscience · 2021Article
- Cortical Mechanisms of Single-Pulse Transcranial Magnetic Stimulation in Migraine.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- Hyperexcitability and impaired intracortical inhibition in patients with fragile-X syndrome.Translational psychiatry · 2019Article
- Intracortical Dynamics Underlying Repetitive Stimulation Predicts Changes in Network Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial magnetic stimulation (TMS) is widely used in clinical interventions and basic neuroscience. Additionally, it has become a powerful tool to drive plastic changes in neuronal networks. However, highly resolved recordings of the immediate TMS effects have remained scarce, because existing recording techniques are limited in spatial or temporal resolution or are interfered with by the strong TMS-induced electric field. To circumvent these constraints, we performed optical imaging with voltage-sensitive dye (VSD) in an animal experimental setting using anaesthetized cats. The dye signals reflect gradual changes in the cells' membrane potential across several square millimeters of cortical tissue, thus enabling direct visualization of TMS-induced neuronal population dynamics. After application of a single TMS pulse across visual cortex, brief focal activation was immediately followed by synchronous suppression of a large pool of neurons. With consecutive magnetic pulses (10 Hz), widespread activity within this "basin of suppression" increased stepwise to suprathreshold levels and spontaneous activity was enhanced. Visual stimulation after repetitive TMS revealed long-term potentiation of evoked activity. Furthermore, loss of the "deceleration-acceleration" notch during the rising phase of the response, as a signature of fast intracortical inhibition detectable with VSD imaging, indicated weakened inhibition as an important driving force of increasing cortical excitability. In summary, our data show that high-frequency TMS changes the balance between excitation and inhibition in favor of an excitatory cortical state. VSD imaging may thus be a promising technique to trace TMS-induced changes in excitability and resulting plastic processes across cortical maps with high spatial and temporal resolutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.