Observational studyEuropean radiology2015
Intravenous contrast injection significantly affects bone mineral density measured on CT.
Observational study in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed.
- Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Trial
- Opportunistic osteoporosis screening on FDG PET/CT scans in breast carcinoma: a comparison with DXA.Asia Oceania journal of nuclear medicine & biology · 2026Article
- Opportunistic osteoporosis screening using multiphase abdominal CT: reliable proximal femur BMD assessment with AI-assisted segmentation.Frontiers in medicine · 2026Article
- Answer to the Letter to the Editor of X. Sun, et al. concerning "Automated extraction of vertebral bone mineral density from imaging with various scan parameters: A cadaver study with correlation to quantitative computed tomography" by C. Ramschütz et al. (Eur Spine J [2025]; doi: 10.1007/s00586-025-09146-8).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- The impact of iodinated contrast medium on bone mineral density (BMD) quantification in computed tomography: a monocentric retrospective study evaluating phases, sex and age differences.La Radiologia medica · 2025Article
- Opportunistic computed tomography (CT) assessment of osteoporosis in patients undergoing transcatheter aortic valve replacement (TAVR).Archives of osteoporosis · 2025Article
- Muscle atrophy and organ enlargement associated with quality of life during systemic therapy for melanoma: findings from an AI-based body composition analysis.European radiology · 2025Article
- Regions of interest in opportunistic computed tomography-based screening for osteoporosis: impact on short-term in vivo precision.Skeletal radiology · 2025Article
- Simulated low-dose multi-detector computed tomography: spatial effects on surrogate parameters of bone strength at the proximal femur.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Effect of contrast media on CT bone density assessment: comparative analysis of low-dose chest CT and abdominopelvic CT.Scientific reports · 2024Article
- Long-Term Reproducibility of BMD-Measurements with Clinical QCT Using Simultaneous and Asynchronous Calibration Methods and Different Measurement and Reconstruction Protocols.Calcified tissue international · 2024Article
- Opportunistic Screening of Bone Fragility Using Computed Tomography.Seminars in musculoskeletal radiology · 2024Review
- The Impact of Contrast Media on Lumbar Spine Bone Mineral Density Measured by Quantitative Computed Tomography.Ethiopian journal of health sciences · 2024Article
- The influence of contrast media on calcium-based imaging of the spine in dual-layer CT.Scientific reports · 2024Article
- Calcium-Based Imaging of the Spine at Dual-Layer CT and Evaluation of Vertebral Fractures in Multiple Myeloma.Cancers · 2024Article
- Coronal plane in opportunistic screening of osteoporosis using computed tomography: comparison with axial and sagittal planes.Skeletal radiology · 2024Article
- Bone density of the cervical, thoracic and lumbar spine measured using Hounsfield units of computed tomography - results of 4350 vertebras.BMC musculoskeletal disorders · 2024Article
- Opportunistic screening for osteoporosis using enhanced images based on dual-energy computed tomography material decomposition: a comparison with quantitative computed tomography.Quantitative imaging in medicine and surgery · 2024Article
- Addressing Challenges of Opportunistic Computed Tomography Bone Mineral Density Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Opportunistic measures of bone mineral density at multiple skeletal sites during whole-body CT in polytrauma patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective is to evaluate the effect of intravenous contrast media on bone mineral density (BMD) assessment by comparing unenhanced and contrast-enhanced computed tomography (CT) examinations performed for other indications.
methodsOne hundred and fifty-two patients (99 without and 53 with malignant neoplasm) who underwent both unenhanced and two contrast-enhanced (arterial and portal venous phase) abdominal CT examinations in a single session between June 2011 and July 2013 were included. BMD was evaluated on the three examinations as CT-attenuation values in Hounsfield Units (HU) in the first lumbar vertebra (L1).
resultsCT-attenuation values were significantly higher in both contrast-enhanced phases, compared to the unenhanced phase (p < 0.01). In patients without malignancies, mean ± standard deviation (SD) HU-values increased from 128.8 ± 48.6 HU for the unenhanced phase to 142.3 ± 47.2 HU for the arterial phase and 147.0 ± 47.4 HU for the portal phase (p < 0.01). In patients with malignancies, HU-values increased from 112.1 ± 38.1 HU to 126.2 ± 38.4 HU and 130.1 ± 37.3 HU (p < 0.02), respectively. With different thresholds to define osteoporosis, measurements in the arterial and portal phase resulted in 7-25% false negatives.
conclusionsOur study showed that intravenous contrast injection substantially affects BMD-assessment on CT and taking this into account may improve routine assessment of low BMD in nonquantitative CT. KEY POINTS: • Routine CT may gain a role in bone attenuation measurements for osteoporosis • Contrast media injection has substantial influence on CT-derived bone density • Contrast-enhanced CT leads to underestimation of osteoporosis compared to unenhanced CT • Adjusting for contrast injection phase may improve CT screening protocols for osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.