ArticleVirology journal2014
Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran.
Article in Virology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Antiviral treatment perspective against Borna disease virus 1 infection in major depression: a double-blind placebo-controlled randomized clinical trial.BMC pharmacology & toxicology · 2020Trial
- Involvement of virus infections and antiviral agents in schizophrenia.Psychological medicine · 2025Review
- Viral infections in etiology of mental disorders: a broad analysis of cytokine profile similarities - a narrative review.Frontiers in cellular and infection microbiology · 2024Review
- Analysis of BoDV-1 status, EEG resting-state alpha activity and pro-inflammatory cytokines in adults with and without major depressive disorder.Frontiers in psychology · 2024Article
- Word recognition memory and serum levels of Borna disease virus specific circulating immune complexes in obsessive-compulsive disorder.BMC psychiatry · 2022Article
- Is latent Toxoplasma gondii infection associated with the occurrence of schizophrenia? A case-control study.PloS one · 2022Article
- Infections, inflammation, and risk of neuropsychiatric disorders: the neglected role of "co-infection".Heliyon · 2020Review
- The pandemic exposes human nature: 10 evolutionary insights.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Low prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of Southern Germany.Scientific reports · 2019Article
- Infectious and immunogenetic factors in bipolar disorder.Acta psychiatrica Scandinavica · 2017Review
- No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran.Iranian journal of microbiology · 2017Article
- Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene-environment interaction study.International journal of bipolar disorders · 2016Article
- Primary psychosis and Borna disease virus infection in Lithuania: a case control study.BMC psychiatry · 2016Article
- Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia.Iranian journal of psychiatry · 2016Article
- Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells.International journal of molecular sciences · 2016Article
- Health care professionals at risk of infection with Borna disease virus - evidence from a large hospital in China (Chongqing).Virology journal · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBorna disease virus (BDV) is an evolutionary old RNA virus, which infects brain and blood cells of humans, their primate ancestors, and other mammals. Human infection has been correlated to mood disorders and schizophrenia, but the impact of BDV on mental-health still remains controversial due to poor methodological and cross-national comparability.
methodThis first report from the Middle East aimed to determine BDV infection prevalence in Iranian acute psychiatric disorder patients and healthy controls through circulating immune complexes (CIC), antibodies (Ab) and antigen (pAg) in blood plasma using a standardized triple enzyme immune assay (EIA). Samples of 314 subjects (114 psychiatric cases, 69 blood donors, and 131 healthy controls) were assayed and data analyzed quantitatively and qualitatively.
resultsCICs revealed a BDV prevalence of one third (29.5%) in healthy Iranian controls (27.5% controls; 33.3% blood donors). In psychiatric patients CIC prevalence was higher than in controls (40.4%) and significantly correlating with bipolar patients exhibiting overt clinical symptoms (p = 0.005, OR = 1.65). CIC values were significantly elevated in bipolar (p = 0.001) and major depressive disorder (p = 0.029) patients as compared to controls, and in females compared to males (p = 0.031).
conclusionThis study supports a similarly high prevalence of subclinical human BDV infections in Iran as reported for central Europe, and provides again an indication for the correlation of BDV infection and mood disorders. Further studies should address the morbidity risk for healthy carriers and those with elevated CIC levels, along with gender disparities.
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