Evidence map›Paper›PMID 25186815›Full record

ReviewJournal of biophotonics2015

Optical hyperspectral imaging in microscopy and spectroscopy - a review of data acquisition.

Liang Gao, R Theodore Smith

Abstract readReview
In one paragraph

Review in Journal of biophotonics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. AI-Enabled Imaging for Pathogen Detection Under Stress Conditions: A Systematic Review.Comprehensive reviews in food science and food safety · 2026
    Pooled it
  2. Pooled it
  3. Hyperspectral Imaging and the Retina: Worth the Wave?Translational vision science & technology · 2020
    Pooled it
  4. Pooled it
  5. Article
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  13. Snapshot hyperspectral fundus imaging system using a microlens array.medRxiv : the preprint server for health sciences · 2025
    Article
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  15. Article
  16. Article
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  18. Article
  19. Review
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Liang GaoDepartment of Biomedical Engineering, Washington University in St. Louis, MO, 63139. gaol@wustl.edu.
R Theodore SmithDepartment of Ophthalmology, NYU School of Medicine, New York, NY, 10016. Roland.Smith@nyumc.org.

Funding

Validated Autofluorescence in Age-Related Macular DegenerationR01EY015520 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMITH, ROLAND THEODORE · 2005 to 2018
$6.0M
Hyperspectral Imaging of the Normal and Age-related Macular Degeneration FundusR01EY021470 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FAWZI, AMANI A, SMITH, ROLAND THEODORE · 2011 to 2014
$3.4M
NEI NIH HHS EY015520NEI NIH HHS EY021470NEI NIH HHS R01 EY015520NEI NIH HHS R01 EY021470
6 · The paper itself

Abstract

Rather than simply acting as a photographic camera capturing two-dimensional (x, y) intensity images or a spectrometer acquiring spectra (λ), a hyperspectral imager measures entire three-dimensional (x, y, λ) datacubes for multivariate analysis, providing structural, molecular, and functional information about biological cells or tissue with unprecedented detail. Such data also gives clinical insights for disease diagnosis and treatment. We summarize the principles underpinning this technology, highlight its practical implementation, and discuss its recent applications at microscopic to macroscopic scales. Datacube acquisition strategies in hyperspectral imaging x, y, spatial coordinates; λ, wavelength.

Indexed as

AnimalsHumansMicroscopyOptical ImagingSpectrum Analysisbiomedical imaginghyperspectral imagingmultispectral imaging

Identifiers

PMID25186815
PMCPMC4348353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.