ArticleEuropean journal of nuclear medicine and molecular imaging2015
Prospective comparison of whole-body (18)F-FDG PET/CT and MRI of the spine in the diagnosis of haematogenous spondylodiscitis.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- FDG-PET-CT as an early detection method for tuberculosis: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Diagnostic accuracy of fluorine-18 fluorodeoxyglucose positron emission tomography for suspected primary and postoperative pyogenic spondylitis.Journal of orthopaedic surgery and research · 2023Pooled it
- Diagnostic performance ofEuropean journal of nuclear medicine and molecular imaging · 2020Pooled it
- The diagnostic value ofEuropean journal of nuclear medicine and molecular imaging · 2018Trial
- Whole-body PET/CT reveals systemic dissemination in spinal tuberculosis: findings from the Spinal TB X cohort.Infection · 2026Article
- Pictorial Review of Paediatric Limp.Pediatric reports · 2025Review
- Article
- Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future Applications.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects.Journal of clinical medicine · 2024Review
- Detection of Spinal Tuberculosis by F-18 FDG PET/CT as a Cause of Unusual Referred Pain in the Right Upper Quadrant of Abdomen.World journal of nuclear medicine · 2022Article
- Spine Infections: The Role of Fluorodeoxyglucose Positron Emission Tomography (FDG PET) in the Context of the Actual Diagnosis Guideline.Current medical imaging · 2022Review
- State of the art ofClinical and translational imaging · 2021Review
- The value ofInternational wound journal · 2020Article
- Incremental value of FDG-PET/CT to monitor treatment response in infectious spondylodiscitis.Skeletal radiology · 2020Observational
- Imaging in the investigation and management of Staphylococcus aureus bacteraemia: a role for advanced imaging techniques.The Journal of hospital infection · 2020Review
- Comparison of the Diagnostic Value of MRI and Whole BodyJournal of clinical medicine · 2020Article
- Clinical usefulness of FDG-PET/CT for identification of abnormal extra-cardiac foci in patients with infective endocarditis.The international journal of cardiovascular imaging · 2020Article
- Joint EANM/ESNR and ESCMID-endorsed consensus document for the diagnosis of spine infection (spondylodiscitis) in adults.European journal of nuclear medicine and molecular imaging · 2019Article
- The role of 18F-FDG PET/CT in early infectious discitis: a case report after a negative MRI.Radiology case reports · 2019Article
- Spondylodiscitis following endovascular abdominal aortic aneurysm repair: imaging perspectives from a single centre's experience.Skeletal radiology · 2018Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo prospectively compare (18)F-FDG PET/CT and MRI in the diagnosis of haematogenous spondylodiscitis
methodsThe study included 26 patients (12 women, 14 men; mean age 59 ± 17 years) with clinical symptoms of infection of the spine. Patients who had had prior spinal surgery or any type of antibiotic therapy in the previous 3 months were excluded from the study. Whole-body PET/CT 60 min after injection of 4.07 MBq/kg of (18)F-FDG and an MRI scan of the spine was performed in all patients. SUVmax in an area surrounding the lesions with the suspicion of infection as well as a background SUVmean in a preserved area of the spine were calculated for quantification. Infection was diagnosed by microbiological documentation in cultures of image-guided spinal puncture fluid or blood. Infection was excluded if symptoms were absent without antimicrobial therapy during a follow-up of at least 6 months.
resultsSpondylodiscitis was confirmed in 18 of the 26 patients. Staphylococcus aureus was found in 8 patients, Mycobacterium tuberculosis in 4, Escherichia coli in 2 and other pathogens in 4. Of the remaining 8 patients, the diagnoses were degenerative spondyloarthropathy in 5 and vertebral fracture in 3. The sensitivity, specificity, and positive and negative predictive value were 83%, 88%, 94% and 70% for (18)F-FDG PET/CT, and 94%, 38%, 77% and 75% for MRI, respectively. The accuracies of (18)F-FDG PET/CT and MRI were similar (84% and 81%, respectively). The combination of (18)F-FDG PET/CT and MRI detected the infection in 100% of the patients with spondylodiscitis. (18)F-FDG uptake, quantified in terms of SUVmax corrected by the background SUVmean, was significantly higher in patients with spondylodiscitis than in those without infection (p < 0.001).
conclusionDue to its high specificity, (18)F-FDG PET/CT should be considered as a first-line imaging procedure in the diagnosis of spondylodiscitis. Quantification of uptake in terms of SUVmax was able to discriminate infection of the spine from other processes in this series of patients.
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