ArticleObesity surgery2015
Changes in glucose transporters, gluconeogenesis, and circadian clock after duodenal-jejunal bypass surgery.
Article in Obesity surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review.Reviews in endocrine & metabolic disorders · 2024Pooled it
- Metabolic Surgery and Diabesity: a Systematic Review.Obesity surgery · 2018Pooled it
- Physiological functions of glucose transporter-2: From cell physiology to links with diabetes mellitus.Heliyon · 2024Review
- Duodenal-Jejunal Bypass Restores Sweet Taste Receptor-Mediated Glucose Sensing and Absorption in Diabetic Rats.Journal of diabetes research · 2024Article
- Intestinal gluconeogenesis: metabolic benefits make sense in the light of evolution.Nature reviews. Gastroenterology & hepatology · 2023Review
- Sodium-glucose co-transporter 1 (SGLT1) differentially regulates gluconeogenesis and GLP-1 receptor (GLP-1R) expression in different diabetic rats: a preliminary validation of the hypothesis of "SGLT1 bridge" as an indication for "surgical diabetes".Annals of translational medicine · 2022Article
- Intestinal gluconeogenesis shapes gut microbiota, fecal and urine metabolome in mice with gastric bypass surgery.Scientific reports · 2022Article
- Altered Glucose Metabolism and Glucose Transporters in Systemic Organs After Bariatric Surgery.Frontiers in endocrinology · 2022Article
- Metabolic benefits of gastric bypass surgery in the mouse: The role of fecal losses.Molecular metabolism · 2020Article
- Residual Gastric Dilatation Interferes with Metabolic Improvements Following Sleeve Gastrectomy by Upregulating the Expression of Sodium-Glucose Cotransporter-1.Obesity surgery · 2019Article
- Additional effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy.Surgery today · 2019Article
- The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism.Cell metabolism · 2019Article
- Weight-Independent Mechanisms of Glucose Control After Roux-en-Y Gastric Bypass.Frontiers in endocrinology · 2018Review
- Roux-en-Y Gastric Bypass Surgery Suppresses Hepatic Gluconeogenesis and Increases Intestinal Gluconeogenesis in a T2DM Rat Model.Obesity surgery · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBariatric surgery improves obesity and ameliorates glucose tolerance. This study was conducted to evaluate circadian clocks, gluconeogenesis, and glucose transport changes in hepatic and intestinal tissues after duodenal-jejunal bypass (DJB) surgery in a rat model.
methodsTwenty-five rats were randomly assigned to either sham group (10 rats) or DJB group (15 rats). Food intake, body weight, blood glucose, and serum insulin levels were measured. Quantitative RT-PCR, immunoblot, and immunohistochemistry were used to analyze genes and proteins in the liver and intestine.
resultsFood intake and body weight were not different between sham and DJB groups. Blood glucose level was significantly lower in the DJB group compared with that in the sham group. Although not significant, serum insulin level showed an increased tendency in DJB group. DJB induced marked expressions of glucose transporter-2 (GLUT2) in the liver and GLUT2 and sodium-dependent glucose transporter-1 (SGLT1) in the intestine. Gluconeogenic enzymes [phosphoenolpyruvate carboxykinase-1 (Pck1) and glucose-6-phosphatase (G6Pase)] decreased in the liver and increased in the intestine of the DJB group. Circadian transcription factor cryptochrome-1 (Cry1) increased in the liver and decreased in the intestine of the DJB group. Another circadian transcription factor period-2 (Per2) also increased in the liver and decreased in the intestine of the DJB group.
conclusionIn conclusion, this study suggests the possibility that Cry1 and Per2 may mediate decreased gluconeogenesis in the liver and increased gluconeogenesis in the intestine of the DJB group.
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Registered trials
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