ArticleAmerican journal of physiology. Renal physiology2014
Live nephron imaging by MRI.
Article in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging.American journal of physiology. Renal physiology · 2022Article
- The old becomes new: advances in imaging techniques to assess nephron mass in children.Pediatric nephrology (Berlin, Germany) · 2021Review
- Parallel magnetic resonance image reconstruction from a single-element parametric amplifier.Magnetic resonance imaging · 2019Article
- High-resolution MRI of kidney microstructures at 7.05 T with an endo-colonic Wireless Amplified NMR detector.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- Signal Sensitivity Enhancement of High-Spatial-Resolution MR Imaging with a Concatenated Cylindrical Parametric RF-Resonator.IEEE sensors journal · 2019Article
- A Novel Expandable Catheter Wireless Amplified NMR Detector for MR Sensitivity Accessing the Kidney in Rodent Model.IEEE transactions on biomedical circuits and systems · 2019Article
- Tracking renal injury using multiparametric MRI.American journal of physiology. Renal physiology · 2018Article
- Wireless amplified NMR detector for improved visibility of image contrast in heterogeneous lesions.NMR in biomedicine · 2018Article
- Sensitive enhancement of vessel wall imaging with an endoesophageal Wireless Amplified NMR Detector (WAND).Magnetic resonance in medicine · 2017Article
- Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls.Scientific reports · 2017Article
- MRI tools for assessment of microstructure and nephron function of the kidney.American journal of physiology. Renal physiology · 2016Review
- Biocompatibility of ferritin-based nanoparticles as targeted MRI contrast agents.Nanomedicine : nanotechnology, biology, and medicine · 2016Article
- Sensory and optogenetically driven single-vessel fMRI.Nature methods · 2016Article
- Counting glomeruli and podocytes: rationale and methodologies.Current opinion in nephrology and hypertension · 2015Review
- Current MRI techniques for the assessment of renal disease.Current opinion in nephrology and hypertension · 2015Review
- 4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice.NMR in biomedicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The local sensitivity of MRI can be improved with small MR detectors placed close to regions of interest. However, to maintain such sensitivity advantage, local detectors normally need to communicate with the external amplifier through cable connections, which prevent the use of local detectors as implantable devices. Recently, an integrated wireless amplifier was developed that can efficiently amplify and broadcast locally detected signals, so that the local sensitivity was enhanced without the need for cable connections. This integrated detector enabled the live imaging of individual glomeruli using negative contrast introduced by cationized ferritin, and the live imaging of renal tubules using positive contrast introduced by gadopentetate dimeglumine. Here, we utilized the high blood flow to image individual glomeruli as hyperintense regions without any contrast agent. These hyperintense regions were identified for pixels with signal intensities higher than the local average. Addition of Mn(2+) allowed the simultaneous detection of both glomeruli and renal tubules: Mn(2+) was primarily reabsorbed by renal tubules, which would be distinguished from glomeruli due to higher enhancement in T1-weighted MRI. Dynamic studies of Mn(2+) absorption confirmed the differential absorption affinity of glomeruli and renal tubules, potentially enabling the in vivo observation of nephron function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.