Evidence map›Paper›PMID 25185947›Full record

ArticleCell metabolism2014

Brown fat in humans: consensus points and experimental guidelines.

Aaron M Cypess, Carol R Haft, Maren R Laughlin, Houchun H Hu

Open access · bronzeAbstract read
In one paragraph

Article in Cell metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 138 citations in OpenAlex.

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  5. Mapping of human brown adipose tissue in lean and obese young men.Proceedings of the National Academy of Sciences of the United States of America · 2017
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  8. Human brown adipose tissue [(15)O]O2 PET imaging in the presence and absence of cold stimulus.European journal of nuclear medicine and molecular imaging · 2016
    Trial
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Aaron M CypessResearch Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Carol R HaftNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: haftc@extra.niddk.nih.gov.
Maren R LaughlinNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: maren.laughlin@nih.gov.
Houchun H HuDepartment of Radiology, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
National Institute of Diabetes and Digestive and Kidney Diseases · USChildren's Hospital of Los Angeles · USJoslin Diabetes Center · US

Funding

Physiological Responses to Activation of Human Brown Adipose TissueZIADK075116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CYPESS, AARON · 2015 to 2025
$6.1M
Intramural NIH HHS Z99 DK999999
6 · The paper itself

Abstract

As part of a current worldwide effort to understand the physiology of human BAT (hBAT) and whether its thermogenic activity can be manipulated to treat obesity, the workshop "Exploring the Roles of Brown Fat in Humans" was convened at the National Institutes of Health on February 25-26, 2014. Presentations and discussion indicated that hBAT and its physiological roles are highly complex, and research is needed to understand the health impact of hBAT beyond thermogenesis and body weight regulation, and to define its interactions with core physiological processes like glucose homeostasis, cachexia, physical activity, bone structure, sleep, and circadian rhythms.

Indexed as

Adipose Tissue, BrownBody WeightEnergy MetabolismFluorodeoxyglucose F18HomeostasisHumansNeckObesityPositron-Emission TomographyThermogenesisFluorodeoxyglucose F18

Identifiers

PMID25185947
PMCPMC4155326
OpenAlexW1966524153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.