ArticleJournal of neurovirology2014
Neurocognitive functioning in a Romanian cohort of young adults with parenterally-acquired HIV-infection during childhood.
Article in Journal of neurovirology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Meta-Analytic Review of the Effect of Antiretroviral Therapy on Neurocognitive Outcomes in Adults Living with HIV-1 in Low-and Middle-Income Countries.Neuropsychology review · 2022Pooled it
- The Impact of Antiretroviral Therapy on Neurocognitive Outcomes Among People Living with HIV in Low- and Middle-Income Countries (LMICs): A Systematic Review.AIDS and behavior · 2021Pooled it
- HIV-related cognitive disorders in children in Kinshasa (Democratic Republic of Congo).BMC public health · 2024Article
- Cognitive impairment in children and adolescents living with perinatal HIV disease in the ART era: a meta-analysis.EClinicalMedicine · 2024Article
- Brain opportunistic infections and tumors in people living with HIV - still a challenge in efficient antiretroviral therapy era.Journal of neurovirology · 2023Observational
- Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents.Life (Basel, Switzerland) · 2023Article
- Challenges and coping strategies among young adults living with perinatally acquired HIV infection in Botswana. A qualitative study.PloS one · 2023Article
- Determinants of health-related quality of life in young adults living with perinatally acquired HIV infection in Botswana.Southern African journal of HIV medicine · 2022Article
- Neurocognitive Impairment in the Combined Antiretroviral Therapy Era in a Romanian Cohort of Young Adults with Chronic HIV Infection.AIDS research and human retroviruses · 2020Article
- Plasma CXCL10 correlates with HAND in HIV-infected women.Journal of neurovirology · 2020Article
- Utility of Using the Montreal Cognitive Assessment (MoCA) as a Screening Tool for HIV-Associated Neurocognitive Disorders (HAND) In Multi-Ethnic Malaysia.AIDS and behavior · 2018Article
- Sex-based differences in neurocognitive functioning in HIV-infected young adults.AIDS (London, England) · 2018Article
- Human Immunodeficiency Virus in the Brain-Culprit or Facilitator?Infectious diseases · 2018Review
- HIV-Associated Neurocognitive Disorders: A Global Perspective.Journal of the International Neuropsychological Society : JINS · 2017Review
- Adolescents with HIV and transition to adult care in the Caribbean, Central America and South America, Eastern Europe and Asia and Pacific regions.Journal of the International AIDS Society · 2017Article
- Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition.Brain, behavior, and immunity · 2017Article
- Latent toxoplasmosis is associated with neurocognitive impairment in young adults with and without chronic HIV infection.Journal of neuroimmunology · 2016Article
- Article
- Impact of Mental Health and Substance Use Disorders on Emergency Department Visit Outcomes for HIV Patients.The western journal of emergency medicine · 2016Article
- Is Tobacco Use Associated with Neurocognitive Dysfunction in Individuals with HIV?Journal of the International Association of Providers of AIDS CareArticle
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Authors and funding
12 authors.
Funding
Abstract
The Romanian cohort can provide valuable information about the effect of chronic HIV-infection and exposure to combined antiretroviral therapy (cART) on the developing brain, based on its unique characteristics: young adults infected parenterally with HIV clade F in the late 1980s and exposed to cART for a decade. We conducted a prospective study using a neuropsychological test battery validated in other international HIV cohorts, in order to evaluate the rate and severity of neurocognitive impairment in a group of young Romanian adults. The 49 HIV-infected (HIV+) participants and the 20 HIV negative (HIV-) controls were similar for age and gender, although the HIV- group tended to be more educated. We found higher cognitive impairment prevalence in the HIV+ group (59.1 %) versus the HIV- group (10 %), and the impairment rate remained significantly higher even when the groups were matched based on the educational level (38.7 % for the HIV+ group vs. 10.0 % for the HIV- controls; p = 0.025). The nadir CD4 count was <200 in 71.4 % of patients, but at the time of neurocognitive assessment, 89.5 % of patients had normal immunological status and 81.8 % undetectable HIV load. Among the HIV-impaired group, 26 % of the participants had syndromic impairment while the other 74 % had asymptomatic neurocognitive impairment. We found a high prevalence of neurocognitive dysfunction in the Romanian young adults growing-up with HIV. The greatest HIV-related cognitive deficits were in the domains of executive and motor functioning, consistent with a frontosubcortical pattern.
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