Evidence map›Paper›PMID 25185826›Full record

ArticleStructure (London, England : 1993)2014

Capturing glimpses of an elusive HIV gp41 prehairpin fusion intermediate.

Lukas K Tamm, Jinwoo Lee, Binyong Liang

Abstract readComment
In one paragraph

Article in Structure (London, England : 1993), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The role of cholesterol in membrane fusion.Chemistry and physics of lipids · 2016
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Lukas K TammCenter for Membrane Biology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: lkt2e@virginia.edu.
Jinwoo LeeCenter for Membrane Biology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Binyong LiangCenter for Membrane Biology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Funding

VIRAL SPIKE GLYCOPROTEIN-MEDIATED MEMBRANE POTENTIALR01AI030557 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI TAMM, LUKAS K · 1991 to 2022
$6.2M
Varenicline for Methamphetamine DependenceR01DA030577 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHOPTAW, STEVEN J · 2011 to 2013
$1.8M
NIAID NIH HHS R01 AI030557NIAID NIH HHS R01 AI30557
6 · The paper itself

Abstract

Nuclear magnetic resonance (NMR) studies on an HIV gp41 construct reported by Lakomek and colleagues in this issue of Structure have revealed the conformational dynamics of a possible trimeric prehairpin fusion intermediate and its interactions with lipids. Two alternative fusion pathways are compared based on this work and a previous NMR structure of a monomeric lipid-bound gp41 ectodomain construct.

Indexed as

HIV Envelope Protein gp41Phosphorylcholinedodecylphosphocholinegp41 protein, Human immunodeficiency virus 1HIV Envelope Protein gp41Phosphorylcholine

Identifiers

PMID25185826
PMCPMC4199205

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.