ArticleEcotoxicology (London, England)2014
Comparison of the sensitivity of seven marine and freshwater bioassays as regards antidepressant toxicity assessment.
Article in Ecotoxicology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Acute toxicity and genotoxicity assessment of environmental contaminants usingArhiv za higijenu rada i toksikologiju · 2026Article
- Article
- Advanced oxidation processes for the removal of antidepressants from wastewater: a comprehensive review.RSC advances · 2025Review
- Understanding Target-Specific Effects of Antidepressant Drug Pollution on Molluscs: A Systematic Review Report.Toxics · 2025Review
- Article
- Comparative Evaluation of Toxicity End Points in Unicellular Bioassays for Environmental Pollutant Assessment.Environmental science & technology · 2025Article
- Influence of Selected Antidepressants on the Ciliated ProtozoanMolecules (Basel, Switzerland) · 2020Article
- Fluoxetine Arrests Growth of the Model DiatomFrontiers in microbiology · 2020Article
- Effect of PHRs and PCPs on Microalgal Growth, Metabolism and Microalgae-Based Bioremediation Processes: A Review.International journal of molecular sciences · 2019Review
- Short-term exposure to tricyclic antidepressants delays righting time in marine and freshwater snails with evidence for low-dose stimulation of righting speed by imipramine.Environmental science and pollution research international · 2019Article
- Toxicity assessment of five emerging pollutants, alone and in binary or ternary mixtures, towards three aquatic organisms.Environmental science and pollution research international · 2018Article
- Testing ZnO nanoparticle ecotoxicity: linking time variable exposure to effects on different marine model organisms.Environmental science and pollution research international · 2018Article
- Assessing the environmental hazard of individual and combined pharmaceuticals: acute and chronic toxicity of fluoxetine and propranolol in the crustacean Daphnia magna.Ecotoxicology (London, England) · 2017Article
- Exposure to SSRI-type antidepressants increases righting time in the marine snail Ilyanassa obsoleta.Environmental science and pollution research international · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hazards linked to pharmaceutical residues like antidepressants are currently a major concern of ecotoxicology because they may have adverse effects on non-target aquatic organisms. Our study assesses the ecotoxicity of three antidepressants (fluoxetine, sertraline and clomipramine) using a battery of marine and freshwater species representing different trophic levels, and compares the bioassay sensitivity levels. We selected the following bioassays: the algal growth inhibition test (Skeletonema marinoi and Pseudokirchneriella subcapitata), the microcrustacean immobilization test (Artemia salina and Daphnia magna), development and adult survival tests on Hydra attenuata, embryotoxicity and metamorphosis tests on Crassostrea gigas, and in vitro assays on primary cultures of Haliotis tuberculata hemocytes. The results showed high inter-species variability in EC50-values ranging from 43 to 15,600 µg/L for fluoxetine, from 67 to 4,400 µg/L for sertraline, and from 4.70 µg/L to more than 100,000 µg/L for clomipramine. Algae (S. marinoi and P. subcapitata) and the embryo-larval stages of the oyster C. gigas were the most sensitive taxa. This raises an issue due to their ecological and/or economic importance. The marine crustacean A. salina was the least sensitive species. This difference in sensitivity between bioassays highlights the importance of using a test battery.
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