ArticleOpen biology2014
Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains.
Article in Open biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The IgA of hares (Frontiers in immunology · 2023Article
- Evolutionary analyses of polymeric immunoglobulin receptor (pIgR) in the mammals reveals an outstanding mutation rate in the lagomorphs.Frontiers in immunology · 2022Article
- Evolution of Fc Receptor-Like Scavenger in Mammals.Frontiers in immunology · 2020Article
- Genetic Diversity ofAnimals : an open access journal from MDPI · 2019Article
- Not so unique to Primates: The independent adaptive evolution of TRIM5 in Lagomorpha lineage.PloS one · 2019Article
- Overcoming species barriers: an outbreak of Lagovirus europaeus GI.2/RHDV2 in an isolated population of mountain hares (Lepus timidus).BMC veterinary research · 2018Article
- Article
- Mechanistic insights into molecular evolution of species-specific differential glycosaminoglycan binding surfaces in growth-related oncogene chemokines.Royal Society open science · 2017Article
- Article
- Positive selection in the SLC11A1 gene in the family Equidae.Immunogenetics · 2016Article
- An overview of the lagomorph immune system and its genetic diversity.Immunogenetics · 2016Review
- Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.Immunogenetics · 2015Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin G (IgG) is the predominant serum immunoglobulin and has the longest serum half-life of all the antibody classes. The European rabbit IgG has been of significant importance in immunological research, and is therefore well characterized. However, the IgG of other leporids has been disregarded. To evaluate the evolution of this gene in leporids, we sequenced the complete IGHG for six other genera: Bunolagus, Brachylagus, Lepus, Pentalagus, Romerolagus and Sylvilagus. The newly sequenced leporid IGHG gene has an organization and structure similar to that of the European rabbit IgG. A gradient in leporid IgG constant domain diversity was observed, with the CH1 being the most conserved and the CH3 the most variable domain. Positive selection was found to be acting on all constant domains, but with a greater incidence in the CH3 domain, where a cluster of three positively selected sites was identified. In the hinge region, only three polymorphic positions were observed. The same hinge length was observed for all leporids. Unlike the variation observed for the European rabbit, all 11 Lepus species studied share exactly the same hinge motif, suggesting its maintenance as a result of an advantageous structure or conformation.
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