Evidence map›Paper›PMID 25185528›Full record

ArticleEuropean journal of pediatrics2015

Early exposure to thimerosal-containing vaccines and children's cognitive development. A 9-year prospective birth cohort study in Poland.

Dorota Mrozek-Budzyn, Renata Majewska, Agnieszka Kiełtyka

Open access · hybridAbstract read
In one paragraph

Article in European journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dorota Mrozek-BudzynDepartment of Epidemiology, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Kopernika 7a St, 31-034, Krakow, Poland, dorota.mrozek-budzyn@uj.edu.pl.
Renata Majewska
Agnieszka Kiełtyka
Jagiellonian University · PL

Funding

VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.R01ES010165 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PERERA, FREDERICA P · 2000 to 2004
$3.2M
Developmental effects of early-life exposure to airborne PAHs.R01ES015282 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PERERA, FREDERICA P · 2009 to 2012
$1.7M
NIEHS NIH HHS R01 ES010165NIEHS NIH HHS R01ES010165NIEHS NIH HHS R01 ES015282NIEHS NIH HHS R01ES015282
6 · The paper itself

Abstract

unlabelledThe controversial topic of the early exposure to mercury is regarding ethylmercury, which is present in the thimerosal-containing vaccines (TCVs). The objective of this study was to determine the relationship between the early exposure to TCVs and cognitive development in children during the first 9 years of life. The cohort included 318 children vaccinated in an early period (neonatal and up to 6 months) against hepatitis B and diphtheria-tetanus-pertussis (DTP) using formulation with or without thimerosal. The children's development was assessed using the Fagan test (6th month of life), the Bayley Scales of Infant Development (BSID)-II (12th-36th month), the Raven test (5th, 8th year), and the Wechsler Intelligence Scale for Children (WISC-R) (6th, 7th, 9th year). Results were determined by multivariable linear and logistic regression, adjusted to potential confounders. Children exposed and not exposed to TCVs in the neonatal period had similar outcomes of cognitive-developmental tests; only the results of BSID-II at the 36th month and WISC-R at the 9th year were significantly higher for those exposed to TCVs. Developmental test results in children exposed to TCVs up to the 6th month of life also did not depend on thimerosal dose.

conclusionTCV administration in early infancy did not affect children's cognitive development.

Indexed as

ChildChild DevelopmentChild, PreschoolCognitionDiphtheria-Tetanus-Pertussis VaccineFemaleHepatitis B VaccinesHumansInfantInfant, NewbornIntelligence TestsMalePolandPreservatives, PharmaceuticalProspective StudiesThimerosalDiphtheria-Tetanus-Pertussis VaccineHepatitis B VaccinesPreservatives, PharmaceuticalThimerosalVaccines

Identifiers

PMID25185528
PMCPMC4334107
OpenAlexW2082839056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.