ArticleAnnals of surgery2015
Long-term Oncologic Outcomes After Neoadjuvant Radiation Therapy for Retroperitoneal Sarcomas.
Article in Annals of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Intensity modulated radiation therapy and surgery for Management of Retroperitoneal Sarcomas: a single-institution experience.Radiation oncology (London, England) · 2017Trial
- Neoadjuvant radiotherapy for primary retroperitoneal well-differentiated liposarcoma: a Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) propensity score matched analysis.EClinicalMedicine · 2026Article
- Data Dissemination of the Role of Neoadjuvant Radiation in Retroperitoneal Sarcoma: A CTOS and CSSO Survey.Current oncology (Toronto, Ont.) · 2023Article
- Retroperitoneal Sarcomas: a Current Review on Management.Indian journal of surgical oncology · 2022Review
- Radiation Therapy for Soft Tissue Sarcoma: Indications, Timing, Benefits, and Consequences.The Surgical clinics of North America · 2022Review
- Factors associated with disease-free and abdominal recurrence-free survival in abdominopelvic and retroperitoneal sarcomas.Journal of surgical oncology · 2022Article
- Article
- ASO Author Reflections: Retroperitoneal Soft Tissue Sarcoma: A Call for Collaboration and Scientific Inquiry.Annals of surgical oncology · 2022Article
- National Trends in Treatment for Retroperitoneal Soft Tissue Sarcoma: A Modern Appraisal of Variability in Therapeutic Strategies.Annals of surgical oncology · 2022Article
- Survival of a patient with multiple-recurrent giant retroperitoneal dedifferentiated liposarcoma for 15 years: A case report.Frontiers in surgery · 2022Article
- Multidisciplinary Management of Retroperitoneal Sarcoma: Diagnosis, Prognostic Factors and Treatment.Cancers · 2021Review
- Perioperative strategy and outcome in giant retroperitoneal dedifferentiated liposarcoma-results of a retrospective cohort study.World journal of surgical oncology · 2020Article
- Role of radiation therapy for retroperitoneal sarcomas: An eight-institution study from the US Sarcoma Collaborative.Journal of surgical oncology · 2019Article
- Neoadjuvant radiotherapy followed by surgery compared with surgery alone in the treatment of retroperitoneal sarcoma: a population-based comparison.Current oncology (Toronto, Ont.) · 2019Article
- Retroperitoneal soft tissue sarcoma: low-dose neoadjuvant radiation therapy followed by surgery with or without intraoperative radiotherapy and adjuvant radiation therapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019Article
- Article
- Radiation Therapy for Retroperitoneal Sarcomas: Influences of Histology, Grade, and Size.Sarcoma · 2018Article
- Effect of intraoperative radiotherapy in the treatment of retroperitoneal sarcoma.International journal of clinical oncology · 2017Article
- [Intra-abdominal and retroperitoneal sarcomas].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016Review
- Soft tissue sarcoma and radiation therapy advances, impact on toxicity.Current treatment options in oncology · 2015Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveTo evaluate long-term survival among patients undergoing radiation therapy (RT), followed by surgical resection of retroperitoneal sarcomas (RPS).
backgroundDespite a lack of level 1 evidence supporting neoadjuvant RT for RPS, its use has increased substantially over the past decade.
methodsThe 1998-2011 National Cancer Data Base was queried to identify patients who underwent resection of RPS. Subjects were grouped by use of neoadjuvant RT. Perioperative variables and outcomes were compared. Multivariable logistic regression was performed to assess predictors of neoadjuvant RT. Groups were propensity matched using a 2:1 nearest neighbor algorithm and short-term outcomes were compared. Finally, long-term survival was evaluated using the Kaplan-Meier method, with comparisons based on the log-rank test.
resultsA total of 11,324 patients were identified. Neoadjuvant RT was administered to 696 patients (6.1%). During the study period, preoperative RT use increased from 4% to nearly 15%. Male sex, tumor size larger than 5 cm, treatment at an academic/research program, and higher tumor grade all predicted neoadjuvant RT administration. After propensity matching, the only difference in baseline characteristics was the use of neoadjuvant chemotherapy. Although neoadjuvant RT was associated with a higher rate of negative margins (77.5% vs 73.0%; P = 0.014), there was no corresponding improvement in 5-year survival (53.2% vs 54.2%; P = 0.695).
conclusionsDespite the increasing use of neoadjuvant RT for patients with RPS, the survival benefit associated with this treatment modality remains unclear. Continued investigation is needed to better define the role of RT among patients with RPS.
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