ArticleThe Journal of general virology2014
Analysis of the long control region of bovine papillomavirus type 1 associated with sarcoids in equine hosts indicates multiple cross-species transmission events and phylogeographical structure.
Article in The Journal of general virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Equine Sarcoid: From BPV-Driven Oncogenesis to Host-Sustained Tumor Persistence.Pathogens (Basel, Switzerland) · 2026Review
- Integrated transcriptomic profiling reveals oncogenic pathways and chimeric transcripts in equine sarcoid lesions with predominant BPV1 detection.Frontiers in molecular biosciences · 2026Article
- Molecular Characterization of BovineVeterinary medicine international · 2025Article
- Interspecies Papillomavirus Type Infection and a Novel Papillomavirus Type in Red Ruffed Lemurs (Viruses · 2023Article
- Bovine Papillomavirus Type 1 Infection in an Equine Congenital Papilloma.Pathogens (Basel, Switzerland) · 2023Article
- New approach for genomic characterisation of equine sarcoid-derived BPV-1/-2 using nanopore-based sequencing.Virology journal · 2022Article
- Inactivation of indicator microorganisms and biological hazards by standard and/or alternative processing methods in Category 2 and 3 animal by-products and derived products to be used as organic fertilisers and/or soil improvers.EFSA journal. European Food Safety Authority · 2021Article
- Screening for bovine papillomavirus type 13 (BPV13) in a European population of sarcoid-bearing equids.Equine veterinary journal · 2021Article
- Electron microscopy and phylogenetic analysis of Bovine papillomavirus infection in cattle from four Egyptian governorates.Tropical animal health and production · 2021Article
- Article
- The characterization of two novel neotropical primate papillomaviruses supports the ancient within-species diversity model.Virus evolution · 2020Article
- Origin and evolution of papillomavirus (onco)genes and genomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Generation of a novel next-generation sequencing-based method for the isolation of new human papillomavirus types.Virology · 2018Article
- Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs.The ISME journal · 2018Article
- Both tumour cells and infiltrating T-cells in equine sarcoids express FOXP3 associated with an immune-supressed cytokine microenvironment.Veterinary research · 2016Article
- Article
- Papillomaviruses: Viral evolution, cancer and evolutionary medicine.Evolution, medicine, and public health · 2015Review
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 7 countries.
Funding
Abstract
Papillomaviruses are a family of slowly evolving DNA viruses and their evolution is commonly linked to that of their host species. However, whilst bovine papillomavirus-1 (BPV-1) primarily causes warts in its natural host, the cow, it can also cause locally aggressive and invasive skin tumours in equids, known as sarcoids, and thus provides a rare contemporary example of cross-species transmission of a papillomavirus. Here, we describe the first phylogenetic analysis of BPV-1 in equine sarcoids to our knowledge, allowing us to explore the evolutionary history of BPV-1 and investigate its cross-species association with equids. A phylogenetic analysis of the BPV-1 transcriptional promoter region (the long control region or LCR) was conducted on 15 bovine and 116 equine samples from four continents. Incorporating previous estimates for evolutionary rates in papillomavirus implied that the genetic diversity in the LCR variants was ancient and predated domestication of both equids and cattle. The phylogeny demonstrated geographical segregation into an ancestral group (African, South American and Australian samples), and a more recently derived, largely European clade. Whilst our data are consistent with BPV-1 originating in cattle, we found evidence of multiple, probably relatively recent, cross-species transmission events into horses. We also demonstrated the high prevalence of one particular sequence variant (variant 20), and suggest this may indicate that this variant shows a fitness advantage in equids. Although strong host specificity remains the norm in papillomaviruses, our results demonstrate that exceptions to this rule exist and can become epidemiologically relevant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.