Evidence map›Paper›PMID 25185005›Full record

ArticleMemorias do Instituto Oswaldo Cruz2014

The Plasmodium bottleneck: malaria parasite losses in the mosquito vector.

Ryan C Smith, Joel Vega-Rodríguez, Marcelo Jacobs-Lorena

Abstract read
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed.

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  11. Compatibility ofTropical medicine and infectious disease · 2025
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  13. Cells · 2025
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  14. Article
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  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryan C SmithDepartment of Molecular Microbiology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health and Immunology, Baltimore, MD, USA.
Joel Vega-RodríguezDepartment of Molecular Microbiology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health and Immunology, Baltimore, MD, USA.
Marcelo Jacobs-LorenaDepartment of Molecular Microbiology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health and Immunology, Baltimore, MD, USA.

Funding

Targeting mosquito organs with phage display librariesR01AI031478 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JACOBS-LORENA, MARCELO · 1991 to 2018
$6.0M
Mechanisms of mosquito midgut invasion by Plasmodium ookinetesR56AI031478 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JACOBS-LORENA, MARCELO · 2014 to 2014
$152k
NIAID NIH HHS AI031478NIAID NIH HHS R01 AI031478NIAID NIH HHS R56 AI031478
6 · The paper itself

Abstract

Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.

Indexed as

AnimalsAnophelesHost-Parasite InteractionsHumansInsect VectorsLife Cycle StagesMalariaPlasmodium

Identifiers

PMID25185005
PMCPMC4156458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.