ArticleThe New England journal of medicine2014
Shattuck Lecture. A molecular basis for nicotine as a gateway drug.
Article in The New England journal of medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Electronic cigarettes and subsequent cigarette smoking in young people: A systematic review.Addiction (Abingdon, England) · 2025Pooled it
- Association between electronic cigarette use and tobacco cigarette smoking initiation in adolescents: a systematic review and meta-analysis.BMC public health · 2021Pooled it
- The social exigencies of the gateway progression to the use of illicit drugs from adolescence into adulthood.Addictive behaviors · 2017Trial
- Paradoxical Ventral Tegmental Area GABA Signaling Drives Enhanced Morphine Reward After Adolescent Nicotine.Biological psychiatry · 2026Article
- Metabolomic and gut microbial biomarkers of smoking cessation treatment in long-term drug therapy: a study protocol for a randomized controlled trial.Frontiers in psychiatry · 2026Article
- Reasons to quit cigarettes, e-cigarettes, and smokeless nicotine products: A cross-sectional study among Danish people aged 15-29 years.Tobacco prevention & cessation · 2026Article
- Attitudes, beliefs, and dependence related to electronic cigarettes among medical students at an eastern Anatolian university: a cross-sectional study.Frontiers in public health · 2026Article
- Disentangling the effects of self-control and the use of tobacco and cannabis on violence perpetration from childhood to early adulthood.European child & adolescent psychiatry · 2025Article
- E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025Review
- Examining the flavor descriptors of e-cigarettes, heated tobacco products, and nicotine pouches in the Philippines: Regulatory challenges and opportunities.PLOS global public health · 2025Article
- Kids No Longer Smoke Cigarettes. Why Aren't We Celebrating?American journal of public health · 2024Article
- Electronic cigarettes and subsequent use of cigarettes in young people: An evidence and gap map.Addiction (Abingdon, England) · 2024Review
- Changes in U.S. Adolescent Nicotine Vaping Prevalence From 2022 to 2023: The Role of Reduced Initiation Three Years Earlier During the Onset of the Pandemic.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- "Tobacco-free nicotine" electronic cigarette perceptions and use among adolescents and adults in five New England states.Addictive behaviors reports · 2024Article
- Cannabis reduction among adolescents as spillover from successful tobacco control.The International journal on drug policy · 2024Article
- Shisha Consumption and Presence of Cotinine in Saliva Samples among Students in Public Universities in Coastal Kenya.Global health, epidemiology and genomics · 2024Article
- Article
- Causation and Common Liability in the Progression of the U.S. Opioid Crisis.Journal of studies on alcohol and drugs · 2024Article
- Declines in Adolescent Substance Use After the COVID-19 Pandemic Onset: The Role of Initiation in Grades 7 and 9.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023Article
- Effects of Serial Polydrug Use on the Rewarding and Aversive Effects of the Novel Synthetic Cathinone Eutylone.Brain sciences · 2023Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.