Evidence map›Paper›PMID 25184829›Full record

ArticleThe American journal of tropical medicine and hygiene2014

In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains.

Peter Ulrich, Gregory R Gipson, Martha A Clark, Abhai Tripathi, David J Sullivan, Carla Cerami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peter UlrichThe Kenneth S. Warren Institute, Ossining, New York; University of North Carolina, Chapel Hill, North Carolina; Johns Hopkins Malaria Institute, Baltimore, Maryland.
Gregory R GipsonThe Kenneth S. Warren Institute, Ossining, New York; University of North Carolina, Chapel Hill, North Carolina; Johns Hopkins Malaria Institute, Baltimore, Maryland.
Martha A ClarkThe Kenneth S. Warren Institute, Ossining, New York; University of North Carolina, Chapel Hill, North Carolina; Johns Hopkins Malaria Institute, Baltimore, Maryland.
Abhai TripathiThe Kenneth S. Warren Institute, Ossining, New York; University of North Carolina, Chapel Hill, North Carolina; Johns Hopkins Malaria Institute, Baltimore, Maryland.
David J SullivanThe Kenneth S. Warren Institute, Ossining, New York; University of North Carolina, Chapel Hill, North Carolina; Johns Hopkins Malaria Institute, Baltimore, Maryland.
Carla CeramiThe Kenneth S. Warren Institute, Ossining, New York; University of North Carolina, Chapel Hill, North Carolina; Johns Hopkins Malaria Institute, Baltimore, Maryland ccerami@unc.edu.

Funding

UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
NCRR NIH HHS UL1 RR025747NCRR NIH HHS UL1RR025747
6 · The paper itself

Abstract

Because of emerging resistance to existing drugs, new chemical classes of antimalarial drugs are urgently needed. We have rationally designed a library of compounds that were predicted to accumulate in the digestive vacuole and then decrystallize hemozoin by breaking the iron carboxylate bond in hemozoin. We report the synthesis of 16 naphthothiazolium salts with amine-bearing side chains and their activities against the erythrocytic stage of Plasmodium falciparum in vitro. KSWI-855, the compound with the highest efficacy against the asexual stages of P. falciparum in vitro, also had in vitro activity against P. falciparum gametocytes and in vivo activity against P. berghei in a murine malaria model.

Indexed as

AminesAnimalsAntimalarialsBenzothiazolesDose-Response Relationship, DrugHumansInhibitory Concentration 50Malaria, FalciparumMiceMice, Inbred C57BLNaphthoquinonesParasitic Sensitivity TestsPlasmodium bergheiPlasmodium falciparumSurface-Active AgentsThiourea2-(cyclohexylimino)-1,2-dihydro-4-methyl-1-(3-(dimethylamino)propyl)naphtho(1,2-d)thiazol-5-olAminesAntimalarialsBenzothiazolesNaphthoquinonesSurface-Active AgentsThiourea

Identifiers

PMID25184829
PMCPMC4183413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.