Evidence map›Paper›PMID 25184673›Full record

ArticleGenes & development2014

Modern genome editing meets telomeres: the many functions of TPP1.

Jan Karlseder

Open access · diamondAbstract readComment
In one paragraph

Article in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jan KarlsederThe Salk Institute, La Jolla, California 92037, USA karlseder@salk.edu.
Salk Institute for Biological Studies · US

Funding

Understanding ALT activation in C. elegans and human cellsR01GM087476 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KARLSEDER, JAN · 2009 to 2017
$3.2M
NIGMS NIH HHS R01 GM087476
6 · The paper itself

Abstract

The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.

Indexed as

HumansShelterin ComplexTelomeraseTelomereTelomere-Binding ProteinsTelomere HomeostasisACD protein, humanShelterin ComplexTelomeraseTelomere-Binding Proteinsembryonic stem cellshuman genome engineeringshelterintelomerasetelomere maintenance

Identifiers

PMID25184673
PMCPMC4197952
OpenAlexW1981503543

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.