ArticleBioMed research international2014
Antiproliferative activity of hamigerone and radicinol isolated from Bipolaris papendorfii.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Recent Advances inJournal of fungi (Basel, Switzerland) · 2022Review
- Fungal Species Causing Maize Leaf Blight in Different Agro-Ecologies in India.Pathogens (Basel, Switzerland) · 2021Article
- EndophyticInsects · 2021Article
- Investigation of biological activity of soil fungal extracts and LC/MS-QTOF based metabolite profiling.Scientific reports · 2021Article
- Efficiency of the Hydroponic System as an Approach to Confirm the Solubilization of CaHPOFrontiers in plant science · 2021Article
- Chimeric protein consisting of 3M2e and HSP as a universal influenza vaccine candidate: from in silico analysis to preliminary evaluation.Virus genes · 2019Article
- Enzyme Inhibitory Radicinol Derivative from Endophytic fungus Bipolaris sorokiniana LK12, Associated with Rhazya stricta.Molecules (Basel, Switzerland) · 2015Article
- Dissecting the fungal biology of Bipolaris papendorfii: from phylogenetic to comparative genomic analysis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
- Endophytic fungi: a reservoir of antibacterials.Frontiers in microbiology · 2014Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary metabolites from fungi organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Through high throughput screening (HTS) and bioassay-guided isolation, we isolated two bioactive compounds hamigerone (1) and radicinol (2). These compounds were isolated from fungus Bipolaris papendorfii, isolated from the rice fields of Dera, Himachal Pradesh, India. The structures of the compounds were established on the basis of spectroscopic data, namely, NMR ((1)H, (13)C, mass, and UV). Both compounds were found to be antiproliferative against different cancer cells. Furthermore we have also noted that both compounds showed increase in apoptosis by favorably modulating both tumor suppressor protein (p53) and antiapoptic protein (BCL-2), and in turn increase caspase-3 expression in cancer cells. This is the first report of these compounds from fungus Bipolaris papendorfii and their anticancer activity.
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