Evidence map›Paper›PMID 25184133›Full record

ArticleBioMed research international2014

CT perfusion in the characterisation of renal lesions: an added value to multiphasic CT.

Francesco Giuseppe Mazzei, Maria Antonietta Mazzei, Nevada Cioffi Squitieri, Chiara Pozzessere, Lorenzo Righi, Alfredo Cirigliano, Susanna Guerrini, Domenico D'Elia, Maria Raffaella Ambrosio, Aurora Barone and 2 more

Abstract read
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Role of Dynamic Perfusion CT in Pancreatic Adenocarcinoma.The Indian journal of radiology & imaging · 2026
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  12. SEOM clinical guideline for treatment of kidney cancer (2019).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Article
  13. Review
  14. Review
  15. Reliability of CT-based texture features: Phantom study.Journal of applied clinical medical physics · 2019
    Article
  16. Article
  17. National trends of preoperative imaging modalities before partial nephrectomy for renal masses in the U.S. from 2007-2015.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2019
    Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesco Giuseppe MazzeiDepartment of Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, Viale Bracci 10, 53100 Siena, Italy.ORCID 0000-0003-2145-7133
Maria Antonietta MazzeiDepartment of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Viale Bracci 10, 53100 Siena, Italy.ORCID 0000-0003-3670-7027
Nevada Cioffi SquitieriDepartment of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Viale Bracci 10, 53100 Siena, Italy.ORCID 0000-0003-4004-5011
Chiara PozzessereDepartment of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Viale Bracci 10, 53100 Siena, Italy.
Lorenzo RighiDepartment of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0001-9915-1332
Alfredo CiriglianoDepartment of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Viale Bracci 10, 53100 Siena, Italy.ORCID 0000-0001-9712-9078
Susanna GuerriniDepartment of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Viale Bracci 10, 53100 Siena, Italy.ORCID 0000-0001-7875-3342
Domenico D'EliaDepartment of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Viale Bracci 10, 53100 Siena, Italy.
Maria Raffaella AmbrosioDepartment of Medical Biotechnologies, Section of Pathology, University of Siena, Viale Bracci 10, 53100 Siena, Italy.
Aurora BaroneDepartment of Medical Biotechnologies, Section of Pathology, University of Siena, Viale Bracci 10, 53100 Siena, Italy.
Maria Teresa del VecchioDepartment of Medical, Surgical and Neuro Sciences, Section of Pathology, University of Siena, Viale Bracci 10, 53100 Siena, Italy.
Luca VolterraniDepartment of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Viale Bracci 10, 53100 Siena, Italy.ORCID 0000-0002-6655-5979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo prospectively evaluate if computed tomography perfusion (CTp) could be a useful tool in addition to multiphasic CT in renal lesion characterisation. MATERIALS AND

methodsFifty-eight patients that were scheduled for surgical resection of a renal mass with a suspicion of renal cell carcinoma (RCC) were enrolled. Forty-one out of 58 patients underwent total or partial nephrectomy after CTp examination, and a pathological analysis was obtained for a total of 49 renal lesions. Perfusion parameters and attenuation values at multiphasic CT for both lesion and normal cortex were analysed. All the results were compared with the histological data obtained following surgery.

resultsPS and MTT values were significantly lower in malignant lesions than in the normal cortex (P < 0.001 and P = 0.011, resp.); PS, MTT, and BF values were also statistically different between oncocytomas and malignant lesions. According to ROC analysis, the accuracy, sensitivity, and specificity to predict RCC were 95.92%, 100%, and 66.7%, respectively, for CTp whereas they were 89.80%, 93.35%, and 50%, respectively, for multiphasic CT.

conclusionA significant difference between renal cortex and tumour CTp parameter values may suggest a malignant renal lesion. CTp could represent an added value to multiphasic CT in differentiating renal cells carcinoma from oncocytoma.

Indexed as

Image Processing, Computer-AssistedTomography, X-Ray ComputedAdultAgedAged, 80 and overCarcinoma, Renal CellFemaleHumansMaleMiddle AgedMultiphasic ScreeningNephrectomy

Identifiers

PMID25184133
PMCPMC4145536

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.