Evidence map›Paper›PMID 25183893›Full record

ArticleThe Canadian veterinary journal = La revue veterinaire canadienne2014

Antibody responses to Bordetella bronchiseptica in vaccinated and infected dogs.

John Ellis, Carrie Rhodes, Stacey Lacoste, Steven Krakowka

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Clinical microbiology reviews · 2023
    Review
  2. The Canadian veterinary journal = La revue veterinaire canadienne · 2021
    Article
  3. Infection and immunity · 2019
    Article
  4. Subcutaneous Immunization of Dogs WithFrontiers in immunology · 2019
    Article
  5. Article
  6. Comparative efficacy of intranasal and injectable vaccines in stimulatingThe Canadian veterinary journal = La revue veterinaire canadienne · 2017
    Article
  7. Serum antibody responses to vaccinal antigens in lean and obese geriatric dogs.The Canadian veterinary journal = La revue veterinaire canadienne · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

John EllisDepartment of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA (Krakowka).
Carrie RhodesDepartment of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA (Krakowka).
Stacey LacosteDepartment of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA (Krakowka).
Steven KrakowkaDepartment of Veterinary Microbiology (Ellis, Rhodes, Lacoste), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4; Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, 43210, USA (Krakowka).
University of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bordetella bronchiseptica (Bb) whole cell bacterins have been replaced with acelluar vaccines. We evaluated the response to the acellular Bb vaccines in Bb-seropositive commingled laboratory beagles and client-owned dogs with various lifestyles and vaccination histories. A single parenteral dose of the acellular Bb vaccine resulted in consistent anamnestic IgG, and to a lesser, but notable extent, IgA, Bb-reactive antibody responses in the seropositive beagles. Associated with the increase in antibodies measured by enzyme-linked immunosorbent assay (ELISA) was an increase in the complement (C)-dependent IgG antibody mediated bactericidal effect on Bb in vitro. Antibody responses in client-owned dogs were more variable and were dependent upon the vaccination history and serological evidence of previous Bb exposure. Antibodies from vaccinated dogs recognized several Bb proteins, notably P68 (pertactin) and P220 (fimbrial hemagglutinin), the response to which has been shown to be disease-sparing in Bp infections. These antibody responses were similar to those in experimentally infected dogs and in dogs that had received a widely used whole cell bacterin.

Indexed as

AnimalsAntibodies, BacterialBacterial VaccinesBordetella bronchisepticaBordetella InfectionsDog DiseasesDogsEnzyme-Linked Immunosorbent AssayFemaleImmunoglobulin GInjections, SubcutaneousMaleVaccinationAntibodies, BacterialBacterial VaccinesImmunoglobulin G

Identifiers

PMID25183893
PMCPMC4137927
OpenAlexW2343255731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.