ReviewCold Spring Harbor perspectives in medicine2014
Modeling cutaneous squamous carcinoma development in the mouse.
Review in Cold Spring Harbor perspectives in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Intrinsic anti-tumorigenic properties of the skin epithelium promote cancer resistance in naked mole-rats.iScience · 2026Article
- PI3Kγ Deficiency Suppresses Cutaneous Squamous Cell Carcinoma Formation by Modulating the Tumour Microenvironment Rather Than by Directly Regulating Keratinocyte Proliferation.Experimental dermatology · 2026Article
- Cutaneous basaloid squamous cell carcinoma in a captive blue-fronted amazon (Brazilian journal of veterinary medicine · 2025Article
- Effect of narrowband ultraviolet B (311 nm) exposure on skin carcinogenesis in Wistar rats.Journal of advanced veterinary and animal research · 2024Article
- DNA damage signalling histone H2AX is required for tumour growth.Cell death discovery · 2024Article
- Advances in cutaneous squamous cell carcinoma.Nature reviews. Cancer · 2023Review
- Tissue memory relies on stem cell priming in distal undamaged areas.Nature cell biology · 2023Article
- Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage.Nature communications · 2023Article
- The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.International journal of molecular sciences · 2022Review
- Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma.International journal of molecular sciences · 2022Review
- PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex.Theranostics · 2022Article
- The Genomic Landscape of Actinic Keratosis.The Journal of investigative dermatology · 2021Article
- Thyroid Hormone Enhances Angiogenesis and the Warburg Effect in Squamous Cell Carcinomas.Cancers · 2021Article
- Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas.Genes & diseases · 2021Article
- The Histopathology of Oral Cancer Pain in a Mouse Model and a Human Cohort.Journal of dental research · 2021Article
- Method to Study Skin Cancer: Two-Stage Chemically Induced Carcinogenesis in Mouse Skin.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch.Nature communications · 2019Article
- Chemopreventive effect of hesperidin, a citrus bioflavonoid in two stage skin carcinogenesis in Swiss albino mice.Heliyon · 2019Article
- Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin.BMC complementary and alternative medicine · 2019Article
- Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers.Frontiers in medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in Caucasian populations and is associated with a significant risk of morbidity and mortality. The classic mouse model for studying SCC involves two-stage chemical carcinogenesis, which has been instrumental in the evolution of the concept of multistage carcinogenesis, as widely applied to both human and mouse cancers. Much is now known about the sequence of biological and genetic events that occur in this skin carcinogenesis model and the factors that can influence the course of tumor development, such as perturbations in the oncogene/tumor-suppressor signaling pathways involved, the nature of the target cell that acquires the first genetic hit, and the role of inflammation. Increasingly, studies of tumor-initiating cells, malignant progression, and metastasis in mouse skin cancer models will have the potential to inform future approaches to treatment and chemoprevention of human squamous malignancies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.