ArticleInvestigative ophthalmology & visual science2014
Response of inner retinal oxygen extraction fraction to light flicker under normoxia and hypoxia in rat.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- A Method to Evaluate the Frequency Dependence of Retinal Vascular and Neural Metrics to Stimulus Modulation.Translational vision science & technology · 2025Article
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Impairment of Neurovascular Function in Intermediate Age-Related Macular Degeneration.Translational vision science & technology · 2024Article
- Article
- Retinal tissue oxygen tension and consumption during light flicker stimulation in rat.Experimental eye research · 2018Article
- A method for volumetric retinal tissue oxygen tension imaging.Current eye research · 2018Article
- A Method for Combined Retinal Vascular and Tissue Oxygen Tension Imaging.Scientific reports · 2017Article
- Retinal oxygen: from animals to humans.Progress in retinal and eye research · 2017Review
- Human retinal imaging using visible-light optical coherence tomography guided by scanning laser ophthalmoscopy.Biomedical optics express · 2015Article
- Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation.Light, science & applications · 2015Article
- Quantitative microvascular hemoglobin mapping using visible light spectroscopic Optical Coherence Tomography.Biomedical optics express · 2015Article
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Authors and funding
4 authors.
Funding
Abstract
purposeOxygen extraction fraction (OEF), defined by the ratio of oxygen metabolism (MO2) to delivery (DO2), determines the level of compensation of MO2 by DO2. In the current study, we tested the hypothesis that inner retinal OEF remains unchanged during light flicker under systemic normoxia and hypoxia in rats due to the matching of MO2 and DO2.
methodsRetinal vascular oxygen tension (PO2) measurements were obtained in 10 rats by phosphorescence lifetime imaging. Inner retinal OEF was derived from vascular PO2 based on Fick's principle. Measurements were obtained before and during light flicker under systemic normoxia and hypoxia. The effects of light flicker and systemic oxygenation on retinal vascular PO2 and OEF were determined by ANOVA.
resultsDuring light flicker, retinal venous PO2 decreased (P < 0.01, N = 10), while inner retinal OEF increased (P = 0.02). Under hypoxia, retinal arterial and venous PO2 decreased (P < 0.01), while OEF increased (P < 0.01). The interaction effect was not significant on OEF (P = 0.52), indicating the responses of OEF to light flicker were similar under normoxia and hypoxia. During light flicker, OEF increased from 0.46 ± 0.13 to 0.50 ± 0.11 under normoxia, while under hypoxia, OEF increased from 0.67 ± 0.16 to 0.74 ± 0.14.
conclusionsInner retinal OEF increased during light flicker, indicating the relative change in DO2 is less than that in MO2 in rats under systemic normoxia and hypoxia. Inner retinal OEF is a potentially useful parameter for assessment of the relative changes of MO2 and DO2 under physiologic and pathologic conditions.
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