ArticleInvestigative ophthalmology & visual science2014
Visuocortical function in infants with a history of neonatal jaundice.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- VEP estimation of visual acuity: a systematic review.Documenta ophthalmologica. Advances in ophthalmology · 2021Pooled it
- Effect of bilirubin on visuocortical development in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Cerebral/Cortical visual impairment (CVI) in Down syndrome: a case series.Frontiers in human neuroscience · 2025Article
- Neonatal microbiome dysbiosis decoded by mNGS: from mechanistic insights to precision interventions.Frontiers in cellular and infection microbiology · 2025Review
- Gut microbial alterations in neonatal jaundice pre- and post-treatment.Bioscience reports · 2021Article
- Contrast Normalization Accounts for Binocular Interactions in Human Striate and Extra-striate Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Meconium microbiome associates with the development of neonatal jaundice.Clinical and translational gastroenterology · 2018Article
- Visuocortical bilirubin-induced neurological dysfunction.Seminars in fetal & neonatal medicine · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeHigh concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level of bilirubin that may be neurotoxic in a given infant is unknown. The aim of this study was to use a quantitative measure of neural activity, the swept parameter visual evoked potential (sVEP) to determine the relationship between neonatal bilirubin levels and visual responsivity several months later.
methodsWe compared sVEP response functions over a wide range of contrast, spatial frequency, and Vernier offset sizes in 16 full-term infants with high bilirubin levels (>10 mg/dL) and 18 age-matched infants with no visible neonatal jaundice, all enrolled at 14 to 22 weeks of age. The group means of sVEP thresholds and suprathreshold response amplitudes were compared. The correlation between individual sVEP thresholds and bilirubin levels in jaundiced infants was studied.
resultsInfants who had a history of neonatal jaundice showed lower response amplitudes (P < 0.05) and worse or immeasurable sVEP thresholds compared with control infants for all three measures (P < 0.05). Swept parameter visual evoked potential thresholds for Vernier offset were correlated with bilirubin level (P < 0.05), but spatial acuity and contrast sensitivity measures in the infants with neonatal jaundice were not (P > 0.05).
conclusionsThese results indicate that elevated neonatal bilirubin levels affect measures of visual function in infancy up to at least 14 to 22 weeks of postnatal age.
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Registered trials
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