ArticleDiagnostic pathology2014
miR-337 regulates the proliferation and invasion in pancreatic ductal adenocarcinoma by targeting HOXB7.
Article in Diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Expression levels of miRNA 22-5p and miRNA 337-5p in bladder cancer.The Indian journal of medical research · 2026Article
- Overexpression of mechanical sensitive miR-337-3p alleviates ectopic ossification in rat tendinopathy model via targeting IRS1 and Nox4 of tendon-derived stem cells.Journal of molecular cell biology · 2020Article
- Early Diagnosis of Pancreatic Ductal Adenocarcinoma by Combining Relative Expression Orderings With Machine-Learning Method.Frontiers in cell and developmental biology · 2020Article
- miR-337 suppresses cutaneous T-cell lymphoma via the STAT3 pathway.Cell cycle (Georgetown, Tex.) · 2019Article
- HDL protects against myocardial ischemia reperfusion injury via miR-34b and miR-337 expression which requires STAT3.PloS one · 2019Article
- Upregulated miR-27a-3p Indicates a Poor Prognosis in Pancreatic Carcinoma Patients and Promotes the Angiogenesis and Migration by Epigenetic Silencing of GATA6 and Activating VEGFA/VEGFR2 Signaling Pathway.OncoTargets and therapy · 2019Article
- Role of miR-337-3p and its target Rap1A in modulating proliferation, invasion, migration and apoptosis of cervical cancer cells.Cancer biomarkers : section A of Disease markers · 2019Article
- Article
- MicroRNA-661 expression is upregulated in pancreatic ductal adenocarcinoma and promotes cell proliferation.Oncology letters · 2018Article
- RBP4 regulates trophoblastic cell proliferation and invasion via the PI3K/AKT signaling pathway.Molecular medicine reports · 2018Article
- MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells.International journal of molecular sciences · 2018Article
- MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4.Cancer biomarkers : section A of Disease markers · 2018Article
- MicroRNA-337 regulates the PI3K/AKT and Wnt/β-catenin signaling pathways to inhibit hepatocellular carcinoma progression by targeting high-mobility group AT-hook 2.American journal of cancer research · 2018Article
- Unveiling massive numbers of cancer-related urinary-microRNA candidates via nanowires.Science advances · 2017Article
- Potential molecular characteristics in situ in response to repetitive UVB irradiation.Diagnostic pathology · 2016Article
- The Widening Sphere of Influence of HOXB7 in Solid Tumors.Cancer research · 2016Review
- Detection of gene communities in multi-networks reveals cancer drivers.Scientific reports · 2015Article
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8 authors.
Funding
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Abstract
backgroundmiRNAs are involved in coordinating a variety of cellular processes by regulating their target genes. Aberrant expression of miRNAs is correlated with various cancers. Previous studies have shown that miR-337 is significantly down-regulated in pancreatic ductal adenocarcinoma (PDAC) and that its expression is negatively correlated to the expression of HOXB7. Both miR-337 and HOXB7 are associated with the prognosis of PDAC patients. The purpose of this study was to identify the molecular mechanisms by which miR-337 acts as a tumor suppressor in PDAC.
methodsSynthetic miR-337 mimics were transfected into PANC-1 and As-PC-1 cells using Lipofectamine™ 2000. The expression of HOXB7 protein was analyzed by Western blot. Luciferase reporter plasmids were constructed to confirm that HOXB7 3'UTR was the target of miR-337. The effect of miR-337 on cell proliferation was evaluated by CCK8 assay and colony formation assay, and cell invasion was evaluated by wound healing assay and transwell assay.
resultsWestern blot and luciferase activity assays identified HOXB7 as the target of miR-337. A CCK-8 assay showed the absorbance of cells transfected with miR-337 mimics to be less than that of control cells, and that the number of cell clones was significantly decreased by miR-337 expression. A wound healing assay showed the invasion rate of cells transfected with miR-337 mimics at 36 h to be markedly lower than in controls. The average number of cells penetrating the Matrigel was significantly lower than the controls.
conclusionThese findings suggest that miR-337 targets HOXB7 and effects significant suppression of PDAC cell proliferation and invasion. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_171.
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