Evidence map›Paper›PMID 25183338›Full record

ArticleAsian Pacific journal of tropical biomedicine2014

Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in long-term iron loading β-thalassemic mice.

Kanokwan Kulprachakarn, Nittaya Chansiw, Kanjana Pangjit, Chada Phisalaphong, Suthat Fucharoen, Robert C Hider, Sineenart Santitherakul, Somdet Srichairatanakool

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of tropical biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Kanokwan KulprachakarnDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Nittaya ChansiwDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Kanjana PangjitCollege of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, Thailand.
Chada PhisalaphongInstitute of Research and Development, Government Pharmaceuticals Organization, Ministry of Public Health, Thailand.
Suthat FucharoenThalassemia Research Center, Institute of Molecular Biosciences, Mahidol University Salaya Campus, Nakornprathom, Thailand.
Robert C HiderInstitute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, London, United Kingdom.
Sineenart SantitherakulMedical Science Research Equipment Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Somdet SrichairatanakoolDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Chiang Mai University · THKing's College London · GBMahidol University · THMinistry of Public Health · THUbon Ratchathani University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the iron-chelating properties and free-radical scavenging activities of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) treatment in chronic iron-loaded β-thalassemic (BKO) mice.

methodsThe BKO mice were fed with a ferrocene-rich diet and were orally administered with CM1 [50 mg/(kg.day)] for 6 months. Blood levels of non-transferrin bound iron, labile plasma iron, ferritin (Ft) and malondialdehyde were determined.

resultsThe BKO mice were fed with an iron diet for 8 months which resulted in iron overload. Interestingly, the mice showed a decrease in the non-transferrin bound iron, labile plasma iron and malondialdehyde levels, but not the Ft levels after continuous CM1 treatment.

conclusionsCM1 could be an effective oral iron chelator that can reduce iron overload and lipid peroxidation in chronic iron overload β-thalassemic mice.

Indexed as

Iron-chelatingIron chelatorIron overloadLipid peroxidationNon-transferrin bound ironβ-thalassemia

Identifiers

PMID25183338
PMCPMC4037662
OpenAlexW2139260503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.