ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2014
Chronic mitochondrial uncoupling treatment prevents acute cold-induced oxidative stress in birds.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Reproductive Drivers of Temporal Telomere Dynamics in Female Tree Swallows.Molecular ecology · 2026Article
- Reactive Oxygen Species: Molecular Mechanisms, Cellular Targets, and Implications for Genomic Stability.BioMed research international · 2026Review
- The cell origin of reactive oxygen species and its implication for evolutionary trade-offs.Open biology · 2025Review
- Response to Food Restriction, but Not Social Information Use, Varies Seasonally in Captive Cardueline Finches.Integrative and comparative biology · 2024Article
- Mutation pressure mediates a pattern of substitution rates with latitude and climate in carnivores.Ecology and evolution · 2024Article
- Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world.Evolutionary applications · 2024Article
- How Does Mitochondrial Protein-Coding Gene Expression inAnimals : an open access journal from MDPI · 2023Article
- Plasticity of mitochondrial function safeguards phosphorylating respiration during in vitro simulation of rest-phase hypothermia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Prenatal thyroid hormones accelerate postnatal growth and telomere shortening in wild great tits.The Journal of experimental biology · 2023Article
- Normal Thermostability of p.Ser113Leu and p.Arg631Cys Variants of Mitochondrial Carnitine Palmitoyltransferase II (CPT II) in Human Muscle Homogenate.Metabolites · 2022Article
- Mitochondrial gene expression in different organs of Hoplobatrachus rugulosus from China and Thailand under low-temperature stress.BMC zoology · 2022Article
- Positive selection over the mitochondrial genome and its role in the diversification of gentoo penguins in response to adaptation in isolation.Scientific reports · 2022Article
- Ecological effects on female bill colour explain plastic sexual dichromatism in a mutually-ornamented bird.Scientific reports · 2021Article
- Testing for context-dependent effects of prenatal thyroid hormones on offspring survival and physiology: an experimental temperature manipulation.Scientific reports · 2020Article
- Signals of selection in the mitogenome provide insights into adaptation mechanisms in heterogeneous habitats in a widely distributed pelagic fish.Scientific reports · 2020Article
- Oxidative stress and mitochondrial responses to stress exposure suggest that king penguins are naturally equipped to resist stress.Scientific reports · 2019Article
- Antioxidant capacity is repeatable across years but does not consistently correlate with a marker of peroxidation in a free-living passerine bird.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Meta-analysis reveals that reproductive strategies are associated with sexual differences in oxidative balance across vertebrates.Current zoology · 2018Article
- Does oxidative stress shorten telomeresBiology letters · 2017Review
- Integrative Approaches for Studying Mitochondrial and Nuclear Genome Co-evolution in Oxidative Phosphorylation.Frontiers in genetics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endotherms have evolved two major types of thermogenesis that allow them to actively produce heat in response to cold exposure, either through muscular activity (i.e. shivering thermogenesis) or through futile electro-chemical cycles (i.e. non-shivering thermogenesis). Amongst the latter, mitochondrial uncoupling is of key importance because it is suggested to drive heat production at a low cost in terms of oxidative stress. While this has been experimentally shown in mammals, the oxidative stress consequences of cold exposure and mitochondrial uncoupling are clearly less understood in the other class of endotherms, the birds. We compared metabolic and oxidative stress responses of zebra finches chronically treated with or without a chemical mitochondrial uncoupler (2,4-dinitrophenol: DNP), undergoing an acute (24 h) and a chronic (4 weeks) cold exposure (12 °C). We predicted that control birds should present at least a transient elevation of oxidative stress levels in response to cold exposure. This oxidative stress cost should be more pronounced in control birds than in DNP-treated birds, due to their lower basal uncoupling state. Despite similar increase in metabolism, control birds presented elevated levels of DNA oxidative damage in response to acute (but not chronic) cold exposure, while DNP-treated birds did not. Plasma antioxidant capacity decreased overall in response to chronic cold exposure. These results show that acute cold exposure increases oxidative stress in birds. However, uncoupling mitochondrial functioning appears as a putative compensatory mechanism preventing cold-induced oxidative stress. This result confirms previous observations in mice and underlines non-shivering thermogenesis as a putative key mechanism for endotherms in mounting a response to cold at a low oxidative cost.
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