ArticlePsychophysiology2015
Do you feel alright? Attenuated neural processing of aversive interoceptive stimuli in current stimulant users.
Article in Psychophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Building the bodily self-awareness: Evidence for the convergence between interoceptive and exteroceptive information in a multilevel kernel density analysis study.Human brain mapping · 2020Pooled it
- Alterations in self-reported sensory gating and interoception in individuals frequently using cannabis.The American journal of drug and alcohol abuse · 2024Article
- Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection.Viruses · 2021Article
- Interoceptive attention in opioid and stimulant use disorder.Addiction biology · 2020Article
- Increased anticipatory brain response to pleasant touch in women remitted from bulimia nervosa.Translational psychiatry · 2020Article
- Do Adolescents Use Substances to Relieve Uncomfortable Sensations? A Preliminary Examination of Negative Reinforcement among Adolescent Cannabis and Alcohol Users.Brain sciences · 2020Article
- Altered anticipation and processing of aversive interoceptive experience among women remitted from bulimia nervosa.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Forging Neuroimaging Targets for Recovery in Opioid Use Disorder.Frontiers in psychiatry · 2019Review
- Neural hypersensitivity to pleasant touch in women remitted from anorexia nervosa.Translational psychiatry · 2018Article
- Insular and cingulate attenuation during decision making is associated with future transition to stimulant use disorder.Addiction (Abingdon, England) · 2017Article
- Under pressure: adolescent substance users show exaggerated neural processing of aversive interoceptive stimuli.Addiction (Abingdon, England) · 2015Article
- Can the neural-cortisol association be moderated by experience-induced changes in awareness?Scientific reports · 2015Article
- Hyperactivation to pleasant interoceptive stimuli characterizes the transition to stimulant addiction.Drug and alcohol dependence · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Inability to appropriately process afferent interoceptive stimuli may contribute to initiation and/or escalation of substance use. An aversive interoceptive stimulus probed neural processing in problem stimulant users (PSU; n = 19), 18 desisted stimulant users (DSU; n = 18), and healthy comparison subjects (CTL; n = 21). Participants completed a continuous performance task while they anticipated and experienced 40 cm H2 O/L/sec inspiratory breathing loads during fMRI. PSU exhibited lower left dorsolateral prefrontal cortex and inferior frontal gyrus (IFG) activation than DSU and CTL across trials. Greater lifetime drug use due to stimulants was also linked to lower activation in these regions. In addition, PSU displayed lower right IFG and insula activation during breathing load than DSU and CTL. Findings suggest that transition to stimulant use disorders is marked by weakened attentional salience of aversive stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.