ArticleAsian Pacific journal of tropical biomedicine2014
Genetic diversity and complexity of Plasmodium falciparum infections in Lagos, Nigeria.
Article in Asian Pacific journal of tropical biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Plasmodium falciparum genetic diversity and multiplicity of infection based on msp-1, msp-2, glurp and microsatellite genetic markers in sub-Saharan Africa: a systematic review and meta-analysis.Malaria journal · 2024Pooled it
- Allelic frequency ofMalariaWorld journal · 2025Article
- Article
- A Comparative Study of Genetic Diversity and Multiplicity of Infection in UncomplicatedPathogens (Basel, Switzerland) · 2024Article
- Exploring the relationship betweenThe Pan African medical journal · 2024Article
- Genetic Diversity of Merozoite Surface Protein-1 and -2 Genes inJournal of parasitology research · 2022Article
- Article
- Genetic diversity of Plasmodium falciparum populations in three malaria transmission settings in Madagascar.Malaria journal · 2021Article
- Genetic diversity and population structure of Plasmodium falciparum in Nigeria: insights from microsatellite loci analysis.Malaria journal · 2021Article
- High-Complexity Plasmodium falciparum Infections, North Central Nigeria, 2015-2018.Emerging infectious diseases · 2019Article
- Characterization of Plasmodium falciparum structure in Nigeria with malaria SNPs barcode.Malaria journal · 2018Article
- Diversity analysis of MSP1 identifies conserved epitope organization in block 2 amidst high sequence variability in Indian Plasmodium falciparum isolates.Malaria journal · 2018Article
- Population Genetics and Molecular Epidemiology of Eukaryotes.Microbiology spectrum · 2018Review
- Molecular approaches to determine the multiplicity of Plasmodium infections.Malaria journal · 2018Review
- Beyond the entomological inoculation rate: characterizing multiple blood feeding behavior and Plasmodium falciparum multiplicity of infection in Anopheles mosquitoes in northern Zambia.Parasites & vectors · 2017Article
- Pro-inflammatory Cytokine Response and Genetic Diversity in Merozoite Surface Protein 2 ofAdvanced biomedical research · 2017Article
- Genetic Diversity and Population Structure of Plasmodium falciparum in Lake Victoria Islands, A Region of Intense Transmission.The American journal of tropical medicine and hygiene · 2016Article
- Genetic Polymorphism of msp1 and msp2 in Plasmodium falciparum Isolates from Côte d'Ivoire versus Gabon.Journal of parasitology research · 2016Article
- Genetic Diversity of Plasmodium falciparum Populations in Malaria Declining Areas of Sabah, East Malaysia.PloS one · 2016Article
- Microsatellite markers reveal low levels of population sub-structuring of Plasmodium falciparum in southwestern Nigeria.Malaria journal · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyse the genetic diversity of Plasmodium falciparum (P. falciparum) using msp-1 and msp-2 as antigenic markers.
methodsParasite DNA was extracted from 100 blood samples collected from P. falciparum-positive patients confirmed by microscopy, and followed by PCR-genotyping targeting the msp-1 (block2) and msp-2 (block 3) allelic families.
resultsAll the families of msp-1 (K1, MAD20 and R033) and msp-2 (FC27 and 3D7) locus were observed. Results revealed that K1 (60/100) was the most predominant genotype of msp-1 allelic family followed by the genotypes of MAD20 (50/100) and R033 (45/100). In the msp-2 locus, FC27 genotype (62/100) showed higher frequency than 3D7 genotype (55/100). The allelic families were detected either alone or in combination with other families. However, no R033/MAD20 combination was observed. Multiplicity of infection (MOI) with msp-1 was higher in the locality of Ikorodu (1.50) than in Lekki (1.39). However, MOI with msp-2 was lower in the locality of Ikorodu (1.14) than in Lekki (1.76). There was no significant difference in the mean MOI between the two study areas (P=0.427).
conclusionsThe observation of limited diversity of malaria parasites may imply that the use of antigenic markers as genotyping tools for distinguishing recrudescence and re-infections with P. falciparum during drug trials is subjective.
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