Evidence map›Paper›PMID 25183081›Full record

ArticleAsian Pacific journal of tropical biomedicine2014

Prevalence of potential drug-drug interactions among internal medicine ward in University of Gondar Teaching Hospital, Ethiopia.

Akshaya Srikanth Bhagavathula, Alemayehu Berhanie, Habtamu Tigistu, Yishak Abraham, Yosheph Getachew, Tahir Mehmood Khan, Chandrashekhar Unakal

Abstract read
In one paragraph

Article in Asian Pacific journal of tropical biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Assessment of potential drug interactions in rheumatology: a comparative study of decision support software.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akshaya Srikanth BhagavathulaDepartment of Clinical Pharmacy Research, School of Pharmacy, University of Gondar, Ethiopia.
Alemayehu BerhanieDepartment of Clinical Pharmacy Research, School of Pharmacy, University of Gondar, Ethiopia.
Habtamu TigistuFaculty of Pharmacy, School of Pharmacy, Gondar, University of Gondar Ethiopia.
Yishak AbrahamFaculty of Pharmacy, School of Pharmacy, Gondar, University of Gondar Ethiopia.
Yosheph GetachewFaculty of Pharmacy, School of Pharmacy, Gondar, University of Gondar Ethiopia.
Tahir Mehmood KhanJeffery Chee School of Medicine and Health Sciences, Monash University, Sunway Campus, 46150, Selangor Darul Ehsan, Malaysia.
Chandrashekhar UnakalDepartment of Medical Microbiology, School of Medicine and Health Sciences, University of Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the prevalence, clinical significance and the associated risk factors of potential drug-drug interactions (DDIs) at internal medicine ward of University of Gondar (UOG) hospital.

methodA prospective cross-sectional study was conducted on patients treated in internal medicine ward of UOG hospital from April 29, 2013 to June 2, 2013. Data was collected from medical records and by interviewing the patients face to face. Descriptive analysis was conducted for back ground characteristics and logistic regression was used to determine the associated risk factors.

resultIn our study, we have identified a total number of 413 potential DDIs and 184 types of interacting combinations with 4.13 potential DDIs per patient. Among 413 potential DDIs most were of moderate interactions 61.2% (n=253) followed by 26% (n=107) of minor interactions and 12.8% (n=53) of major interactions. There was significant association of occurrence of potential DDIs only with taking three or more medications.

conclusionWe have recorded a high rate of prevalence of potential DDI in the internal medicine ward of UOG hospital and a high number of clinically significant DDIs which the most prevalent DDI were of moderate severity. Careful selection of drugs and active pharmaceutical care is encouraged in order to avoid negative consequences of these interactions.

Indexed as

Drug-drug interactionsEthiopiaPrescriptionPrevalenceRisk factors

Identifiers

PMID25183081
PMCPMC4025339

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.