Evidence map›Paper›PMID 25183077›Full record

ArticleAsian Pacific journal of tropical biomedicine2014

α:Non-α and Gγ:Aγ globin chain ratios in thalassemia intermedia patients treated with hydroxyurea.

Abbas Najjari, Mohsen Asouri, Ladan Hosseini Gouhari, Haleh Akhavan Niaki, Amir Sasan Mozaffari Nejad, Seyyedeh Masoumeh Eslami, Hassan Abolghasemi, Ramin Ataee, Abdol Ali Ebrahimi, Masoumeh Rezaei Moshaei and 1 more

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In one paragraph

Article in Asian Pacific journal of tropical biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 1 country.

Abbas NajjariCentre for collective, reflection & implementation of ideas, Undersecretary for Research and Technology, Ministry of Health and Medical Education, Tehran, Iran.
Mohsen AsouriNorth Research Center, Pasteur Institute of Iran, Amol, Iran ; 17th Shahrivar Hospital, Mazandaran University of Medical Sciences, Amol, Iran.
Ladan Hosseini GouhariIran University of Medical Sciences, School of Paramedicine, Cellular and Molecular Research Center, Tehran, Iran.
Haleh Akhavan NiakiCellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
Amir Sasan Mozaffari NejadYoung Researchers and Elite Club, Sari Branch, Islamic Azad University, Sari, Iran.
Seyyedeh Masoumeh EslamiImam Reza Hospital, Mazandaran University of Medical Sciences, Amol, Iran.
Hassan AbolghasemiShabid Beheshti University of Medical Sciences, Tehran, Iran.
Ramin AtaeePharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Abdol Ali EbrahimiShabid Beheshti University of Medical Sciences, Tehran, Iran.
Masoumeh Rezaei MoshaeiDepartment of Plant Breeding and Biotechnology, Agricultural sciences & Natural Resources University of Sari, Iran.
Ali Asghar AhmadiNorth Research Center, Pasteur Institute of Iran, Amol, Iran.
Mazandaran University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRBabol University of Medical Sciences · IRImam Reza Hospital · IRIran University of Medical Sciences · IRIslamic Azad University Sari Branch · IRMinistry of Health and Medical Education · IRPasteur Institute of Iran · IRSari Agricultural Sciences and Natural Resources University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo elucidate the possible ways by which hydroxyurea molecules affect globin chain (α or β-like) synthesis.

methodsA total of 23 thalassemia intermedia patients (13 male and 10 female) aged between 5 and 26 years were treated for five months with 15 mg/(kg·day) of hydroxyurea. Hemoglobins electrophoresis and globin chain electrophoresis was performed on each sample at different time points before and during the treatment.

resultsFetal hemoglobin increased significantly in most patients and average episodes of transfusion decreased. Both Gγ and Aγ-globin chains increased significantly and α-globin:Nonα-globin chain as well as Gγ-globin:Aγ globin chains ratios decreased.

conclusionsImprovement in α:non-α ratio and consequent decrease of free α-globin chain might be the cause of beneficial effects of hydroxyurea therapy. Two patients who felt better didn't show significant increase in their fetal hemoglobin level, and this is in contradiction with the hypothesis claiming that the HbF level increase is the cause of such therapeutic effect. In spite of the unclear mechanism of action of this drug, hydroxyurea therapy had noticeable impacts on thalassemia intermedia and also sickle cell disease and even patients suffering from thalassemia major.

Indexed as

AUT-PAGEGlobin chainHemoglobinHydroxyureaThalassemia intermedia

Identifiers

PMID25183077
PMCPMC4025300
OpenAlexW1982395978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.